Structural characteristics of small-molecule inhibitors targeting demethylase.

Studies have shown that the gene is closely related to obesity and weight gain in humans. is an N-methyladenosine demethylase and is linked to an increased risk of obesity and a variety of diseases, such as acute myeloid leukemia, type 2 diabetes, breast cancer, glioblastoma and cervical squamous cell carcinoma. In light of the significant role of , the development of small-molecule inhibitors targeting the protein provides not only a powerful tool for grasping the active site of but also a theoretical basis for the design and synthesis of drugs targeting the protein. This review focuses on the structural characteristics of inhibitors and discusses the occurrence of obesity and cancer caused by gene overexpression.