Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, BC Children's Hospital and University of British Columbia, Vancouver, British Columbia, Canada.
Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, BC Children's Hospital and University of British Columbia, Vancouver, British Columbia, Canada.
Curr Opin Microbiol. 2021 Oct;63:76-82. doi: 10.1016/j.mib.2021.06.004. Epub 2021 Jul 6.
Enteric bacterial infections impose a significant and global health burden on society, and their threat is increasing in concert with a rise in antibiotic resistance. There is thus a great need to quickly develop new antimicrobial treatments and interest is growing in targeting pathogen nutrition and metabolism. In this review, we highlight recent research on the metabolism of Citrobacter rodentium, a murine-specific relative of enteropathogenic Escherichia coli (EPEC) and enterohemorrhagic E. coli (EHEC). We focus on the mechanisms by which C. rodentium acquires nutrients as well as the distinct metabolic strategies that C. rodentium employs in varying spatiotemporal niches. We propose that identifying and targeting nutrients found essential for bacterial pathogenesis is an attractive anti-microbial approach in the new post-antibiotic era.
肠细菌感染对社会造成了重大的全球健康负担，而且随着抗生素耐药性的增加，这种威胁也在增加。因此，迫切需要开发新的抗菌治疗方法，人们对靶向病原体营养和代谢的兴趣日益浓厚。在这篇综述中，我们强调了最近关于鼠柠檬酸杆菌（一种与肠致病性大肠杆菌（EPEC）和肠出血性大肠杆菌（EHEC）相关的特定于鼠的细菌）代谢的研究。我们重点介绍了柠檬酸杆菌获取营养的机制，以及柠檬酸杆菌在不同时空小生境中采用的独特代谢策略。我们提出，在新的后抗生素时代，确定和靶向对细菌发病机制至关重要的营养物质是一种有吸引力的抗菌方法。
