Johansson S, Cohen S M, Yang J P, Arai M, Friedell G H
Invest Urol. 1978 Jan;15(4):308-77.
The effect of N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide (FANTF) and phenacetin on the immune status of Fischer rats was determined utilizing the spleen plaque and phytohemagglutinin blastogenesis assays 6, 10, and 15 weeks after administration at doses of 0.2 per cent and 0.535 per cent, respectively. Azathioprine (0.02 per cent of the diet) was tested as a known immunosuppressive chemical for comparison, and a negative control group, fed a control diet without added chemicals, was also tested. Immunosuppression was shown in the rats receiving azathioprine at all times by both assays, whereas in FANFT-fed rats immunosuppression was greater than in the control group (not statistically significant). Results from rats fed phenacetin were not significantly different than those of the control group. These results show that immunosuppression does not occur in rats administered phenacetin for up to 15 weeks, nor in FANFT-induced bladder carcinogenesis at the time of reversible bladder mucosal hyperplasia (6 weeks), or when the mucosal lesions have become irreversible, non-invasive carcinomas (10 and 15 weeks).
分别以0.2%和0.535%的剂量给予N-[4-(5-硝基-2-呋喃基)-2-噻唑基]甲酰胺（FANTF）和非那西丁，在给药后6周、10周和15周，利用脾集落和植物血凝素刺激淋巴细胞增殖试验测定其对Fischer大鼠免疫状态的影响。将硫唑嘌呤（占饮食的0.02%）作为一种已知的免疫抑制化学物质进行测试以作比较，同时还测试了一个阴性对照组，该组喂食不添加化学物质的对照饮食。两种试验均显示，在所有时间点接受硫唑嘌呤的大鼠均出现免疫抑制，而在喂食FANFT的大鼠中，免疫抑制程度大于对照组（无统计学意义）。喂食非那西丁的大鼠的结果与对照组无显著差异。这些结果表明，给予非那西丁长达15周的大鼠未发生免疫抑制，在FANFT诱导的膀胱致癌过程中，在膀胱黏膜增生可逆时（6周），或当黏膜病变已变为不可逆的非侵袭性癌时（10周和15周）也未发生免疫抑制。
