Department of Ophthalmology, The First Hospital of China Medical University, 155 Nanjingbei Street, Heping District, Shenyang, 110001, People's Republic of China.
Department of Neurology, People's Hospital, China Medical University, 33 Wenyi Road, Shenhe District, Shenyang, 110016, People's Republic of China.
J Neurol. 2022 Mar;269(3):1272-1281. doi: 10.1007/s00415-021-10703-6. Epub 2021 Jul 10.
To investigate the retina thickness assessed using optical coherence tomography in atypical parkinsonism in comparison with health controls (HC) and patients with Parkinson's disease (PD).
PubMed and EMBASE were searched for potentially eligible studies that reported retina thickness in atypical parkinsonism [including progressive supranuclear palsy (PSP), multiple system atrophy (MSA) and corticobasal degeneration] in comparison with that of HC and PD patients from their dates of inception to Jan 24, 2021. Mean difference (μm) of the thickness of peripapillary retinal nerve fiber layer (pRNFL) and central macular thickness (CMT) were pooled with random effects model.
We included ten studies eligible for inclusion criteria. Average pRNFL thickness and average CMT were thinner in PSP [pooled mean difference (μm) of - 4.71, 95% CI (- 7.15, - 2.27); - 15.12, 95% CI (- 16.93, - 13.30)] and in MSA [- 5.37, 95% CI (- 6.59, - 4.15); - 5.93, 95% CI (- 11.00, - 0.87)] compared with HC, and were thinner in PSP [- 5.81, 95% CI (- 8.92, - 2.69); - 10.63, 95% CI (- 20.29, - 0.98)] and in MSA [- 0.35 μm, 95% CI (- 5.72, 5.01); - 7.42 μm [95% CI (- 12.46, - 2.38)] compared with PD. The pRNFL thickness was thinning in superior, inferior and nasal quadrants, and CMT was thinning in outer sectors in MSA compared with HC.
The retina thickness was significantly thinner in PSP and MSA than those in HC and PD. The specific patterns of retina thinning in MSA could be clinical importance for differentiation among atypical parkinsonism.
利用光学相干断层扫描（OCT）评估非典型帕金森病患者的视网膜厚度，并与健康对照者（HC）和帕金森病（PD）患者进行比较。
从建库起至 2021 年 1 月 24 日，检索 PubMed 和 EMBASE 中可能符合纳入标准的研究，这些研究报告了非典型帕金森病（包括进行性核上性麻痹（PSP）、多系统萎缩（MSA）和皮质基底节变性）患者的视网膜厚度，并与 HC 和 PD 患者的视网膜厚度进行了比较。使用随机效应模型对周边视网膜神经纤维层（pRNFL）和中心黄斑厚度（CMT）的厚度平均值差异（μm）进行汇总。
我们纳入了符合纳入标准的 10 项研究。PSP 患者的 pRNFL 平均厚度和 CMT 平均厚度较 HC 变薄[平均差异（μm）为-4.71，95%置信区间（CI）（-7.15，-2.27）；-15.12，95%CI（-16.93，-13.30）]，MSA 患者变薄[平均差异（μm）为-5.37，95%CI（-6.59，-4.15）；-5.93，95%CI（-11.00，-0.87）]，PSP 患者变薄[平均差异（μm）为-5.81，95%CI（-8.92，-2.69）；-10.63，95%CI（-20.29，-0.98）]，MSA 患者变薄[平均差异（μm）为-0.35μm，95%CI（-5.72，5.01）；-7.42μm，95%CI（-12.46，-2.38）]。与 HC 相比，MSA 患者的 pRNFL 厚度变薄，上、下和鼻象限变薄，CMT 变薄，外区变薄。
PSP 和 MSA 患者的视网膜厚度明显薄于 HC 和 PD 患者。MSA 中视网膜变薄的特定模式可能对非典型帕金森病的鉴别具有临床意义。
