帕金森病和非典型帕金森综合征的视网膜结构异常。
Retinal Structure Abnormalities in Parkinson's Disease and Atypical Parkinsonism.
机构信息
Department of Neurology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing 100730, China.
Department of Ophthalmology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing 100730, China.
出版信息
Biomolecules. 2023 Jan 23;13(2):218. doi: 10.3390/biom13020218.
We investigated retinal structure changes in patients with Parkinson's disease (PD), multiple system atrophy (MSA), progressive supranuclear palsy (PSP), and controls, and explored the value of this method in differential diagnosis. Spectral domain optical coherence tomography (SD-OCT) was used to measure peripapillary retinal nerve fiber layer (pRNFL) thickness, and macular thickness and volume. PSP patients showed higher temporal pRNFL thickness than PD and MSA patients. Peripapillary RNFL thickness could be used for discriminating PSP from MSA and PD. PD and MSA patients showed retinal thinning in the foveal center circle and nasal inner sectors compared to controls. Macular thickness and volume could be used for discriminating MSA from PD. There were negative correlations between disease duration and OCT parameters in PD, MSA, and PSP, independent of age, sex ratio, and the side of the eye. PD and atypical parkinsonism correlate with specific patterns of retina alterations. OCT could be a biomarker for differential diagnosis and progression evaluation of parkinsonian syndrome.
我们研究了帕金森病（PD）、多系统萎缩（MSA）、进行性核上性麻痹（PSP）患者和对照组的视网膜结构变化，并探讨了该方法在鉴别诊断中的价值。使用频域光学相干断层扫描（SD-OCT）测量了视盘周围视网膜神经纤维层（pRNFL）厚度以及黄斑厚度和体积。PSP 患者的颞侧 pRNFL 厚度高于 PD 和 MSA 患者。视盘周围 RNFL 厚度可用于区分 PSP 与 MSA 和 PD。与对照组相比，PD 和 MSA 患者的黄斑中心凹和鼻侧内区视网膜变薄。黄斑厚度和体积可用于区分 MSA 与 PD。PD、MSA 和 PSP 患者的疾病持续时间与 OCT 参数呈负相关，与年龄、性别比和眼侧无关。PD 和非典型帕金森病与特定的视网膜改变模式相关。OCT 可能成为帕金森综合征鉴别诊断和进展评估的生物标志物。
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