在园螺（Cepaea hortensis）中磺胺甲恶唑和N4-乙酰磺胺甲恶唑的乙酰化、去乙酰化及羟基化作用
Acetylation, deacetylation and hydroxylation of sulphamethoxazole and N4-acetylsulphamethoxazole in the snail Cepaea hortensis.
作者信息
Vree T B, Vree M L, Nouws J F
机构信息
Department of Clinical Pharmacy, Sint Radboud Hospital, University of Nijmegen, The Netherlands.
出版信息
Vet Q. 1987 Oct;9(4):378-81. doi: 10.1080/01652176.1987.9694129.
PMID:3424644
Abstract
The snail Cepaea hortensis is able to acetylate and hydroxylate sulphamethoxazole in a similar way to man. About one percent deacetylation, but no hydroxylation of N4-acetysulphamethoxazole takes place. The relative rates of the metabolic pathways for hydroxylation and acetylation of sulphamethoxazole are equal.
摘要
蜗牛园螺（Cepaea hortensis）能够以与人类相似的方式对磺胺甲恶唑进行乙酰化和羟基化。N4 - 乙酰磺胺甲恶唑发生约1%的脱乙酰化，但没有羟基化。磺胺甲恶唑羟基化和乙酰化代谢途径的相对速率相等。
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