Vree T B, Vree J B
Vet Q. 1984 Jul;6(3):169-73. doi: 10.1080/01652176.1984.9693932.
Sulfamethoxazole and N4-acetylsulfamethoxazole are excreted by fresh water turtles Pseudemys scripta elegans in a biphasic mode, characterized half-lives of 5 and 100 min. Acetylation and deacetylation reactions cannot be detected below a dose of 50 mg/kg. The mass balance of the dose administered is incomplete, only 30 per cent of the dose can be recovered as parent compound and metabolite. The sulfonamides must be mainly excreted by the faeces and may be metabolized in the gastro-intestinal tract.
磺胺甲恶唑和N4-乙酰磺胺甲恶唑以双相模式由淡水龟丽彩龟排出，其特征性半衰期分别为5分钟和100分钟。在剂量低于50mg/kg时无法检测到乙酰化和去乙酰化反应。给药剂量的质量平衡不完整，只有30%的剂量可以作为母体化合物和代谢物回收。磺胺类药物必须主要通过粪便排出，并且可能在胃肠道中代谢。
