Department of Periodontology, Faculty of Dentistry, Sakarya University, Sakarya, Turkey.
Department of Internal Medicine, Faculty of Medicine, Sakarya University, Sakarya, Turkey.
Microvasc Res. 2021 Nov;138:104222. doi: 10.1016/j.mvr.2021.104222. Epub 2021 Jul 8.
The aim of this study was to evaluate the possible microcircularity variations at periodontal mucous level in patients with gestational diabetes mellitus (GDM).
Overall 55 periodontally healthy and non-smoker participants were enrolled in the study by whom 30 were diagnosed with GDM (26 to 34 weeks pregnant) and 25 were systemically healthy unpregnant controls. The analysis was performed in the masticatory/gingival mucosa of maxillary anterior region and by the optical probe videocapillaroscopy technique equipped with 200× lenses. The following parameters were recorded: capillary loop visibility, capillary orientation to surface, microhemorrhages, capillary density and tortuosity.
The average capillary density was significantly higher in participants with GDM (27 ± 5.46 no. loops/mm) compared to controls (21.16 ± 3 no. loops/mm) (P = 0.035) while increased tortuosity scores was observed in controls compared with the GDM group (P = 0.017). There was not any significantly difference between study groups among the other variables (P > 0.05).
Capillary alterations including capillary density and tortuosity were demonstrated in gingival microcirculation of patients with GDM. These microcirculatory changes could provide us new understanding on the dynamics of the relationship between GDM and periodontal tissues.
本研究旨在评估妊娠期糖尿病（GDM）患者牙周黏膜水平微循环变化的可能性。
通过光学探头视频毛细血管镜技术（配备 200×镜头），对 55 名牙周健康且不吸烟的参与者的上颌前区咀嚼/牙龈黏膜进行分析，其中 30 名参与者被诊断为 GDM（妊娠 26 至 34 周），25 名参与者为系统健康的未怀孕对照组。记录以下参数：毛细血管环可见性、毛细血管与表面的方向、微出血、毛细血管密度和迂曲度。
与对照组（21.16±3 个循环/mm）相比，GDM 组（27±5.46 个循环/mm）的平均毛细血管密度显著更高（P=0.035），而对照组的迂曲度评分高于 GDM 组（P=0.017）。两组间其他变量无显著差异（P>0.05）。
GDM 患者的牙龈微循环显示出毛细血管密度和迂曲度的改变。这些微循环变化可能使我们对 GDM 与牙周组织之间关系的动态有新的认识。
