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剖宫产术后腰方肌或腹横肌平面阻滞用于术后镇痛:一项双盲随机试验

Quadratus lumborum or transversus abdominis plane block for postoperative analgesia after cesarean: a double-blinded randomized trial.

作者信息

Jadon Ashok, Amir Mohammad, Sinha Neelam, Chakraborty Swastika, Ahmad Asif, Mukherjee Sudeshna

机构信息

Tata Motors Hospital, Department of Anesthesia & Pain Relief Service, Jamshedpur, India.

Tata Motors Hospital, Department of Anesthesia & Pain Relief Service, Jamshedpur, India.

出版信息

Braz J Anesthesiol. 2022 Jul-Aug;72(4):472-478. doi: 10.1016/j.bjane.2021.06.014. Epub 2021 Jul 8.

Abstract

BACKGROUND

Multimodal analgesia (MMA) is the current standard practice to provide post-cesarean analgesia. The aim of this study was to compare the analgesic efficacy of quadratus lumborum (QL) block and transversus abdominis plane (TAP) block as an adjunct to MMA.

METHODS

Eighty mothers undergoing cesarean delivery under spinal anesthesia were randomized to receive either TAP or transmuscular QL block (QLB) with 20 mL 0.375% ropivacaine on each side. Postoperatively, all the subjects were assessed at 2, 4, 6, 8, 12, 18, and 24 hours. The primary outcome was the time to first analgesic request. The secondary outcomes were the pain scores during rest and movement, number of doses of tramadol, postoperative nausea-vomiting, sedation, and mother's satisfaction with the pain management.

RESULTS

The median (IQR) time to first analgesic request was 12 (9.25, 13) hours in the QL group and 9 (8.25, 11.37) hours in the TAP group (p = 0.0008). Patients in QL group consumed less doses of tramadol than those in TAP group (p < 0.0001). Pain scores were significantly lower in the QL group at all time points (p < 0.0001) except at 8 hour when at rest, p = 0.0024, and on movement, p = 0.0028. The maternal satisfaction was significantly higher in the QL group (p = 0.0017).

CONCLUSION

Our study showed the significant delay in time to first analgesic request in QL group patients. Patients in the QL group had lower pain scores, required fewer analgesic supplements, and had more satisfaction. Nausea-vomiting and sedation were comparable.

摘要

背景

多模式镇痛(MMA)是目前剖宫产术后镇痛的标准做法。本研究的目的是比较腰方肌(QL)阻滞和腹横肌平面(TAP)阻滞作为MMA辅助手段的镇痛效果。

方法

80例行脊髓麻醉下剖宫产的产妇被随机分为两组,分别接受双侧20 mL 0.375%罗哌卡因的TAP阻滞或经肌肉QL阻滞(QLB)。术后,在2、4、6、8、12、18和24小时对所有受试者进行评估。主要结局是首次镇痛需求时间。次要结局包括静息和活动时的疼痛评分、曲马多剂量、术后恶心呕吐、镇静情况以及产妇对疼痛管理的满意度。

结果

QL组首次镇痛需求的中位(IQR)时间为12(9.25,13)小时,TAP组为9(8.25,11.37)小时(p = 0.0008)。QL组患者的曲马多剂量低于TAP组(p < 0.0001)。除8小时静息时(p = 0.0024)和活动时(p = 0.0028)外,QL组在所有时间点的疼痛评分均显著更低(p < 0.0001)。QL组产妇的满意度显著更高(p = 0.0017)。

结论

我们的研究显示QL组患者首次镇痛需求时间显著延迟。QL组患者疼痛评分更低,所需镇痛补充剂更少,满意度更高。恶心呕吐和镇静情况相当。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd03/9373105/df55d1bb9680/gr1.jpg

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