Department of Biochemistry, Federal Urdu University of Arts, Science and Technology, Karachi, Pakistan.
Pak J Pharm Sci. 2021 Jan;34(1):165-170.
Gentamicin (GM) is a generally utilized as an antibiotic against dangerous and life threatening contaminations, yet its value is restricted by the development of nephrotoxicity. The present investigation was intended to decide the defensive impact of salicylic acid (SA) in gentamicin-induced nephrotoxicity in rabbits. Quantitative assessment of gentamicin-induced structural changes and level of functional modifications in the kidneys were performed by biochemical examinations keeping in mind the end goal is to decide the potential protective impacts of SA co-administration with gentamicin. Gentamicin was seen to cause a serious nephrotoxicity which was proved by a plasma urea, plasmacreatinine, plasma uric acid, plasma Na, plasma K, intra-erythrocyte Na and intra-erythrocyte K levels. On the other hand, simultaneous SA administration protected kidney tissue against the oxidative damage and the nephrotoxic effect caused by GM treatment. The outcomes from our investigation show that SA supplement lessens oxidative-stress related to renal damage by reducing oxygen free radicals in gentamicin-treated rabbits.
庆大霉素（GM）是一种常用的抗生素，用于对抗危险和危及生命的感染，但由于其肾毒性的发展，其应用受到限制。本研究旨在探讨水杨酸（SA）对兔庆大霉素诱导的肾毒性的保护作用。通过生化检查定量评估庆大霉素诱导的肾脏结构变化和功能改变，旨在确定 SA 与庆大霉素联合给药的潜在保护作用。结果表明，庆大霉素引起严重的肾毒性，这可以通过血浆尿素、血浆肌酐、血浆尿酸、血浆 Na、血浆 K、红细胞内 Na 和红细胞内 K 水平得到证明。另一方面，同时给予 SA 可防止肾组织免受 GM 治疗引起的氧化损伤和肾毒性作用。我们的研究结果表明，SA 补充通过减少庆大霉素处理兔中的氧自由基来减轻与肾损伤相关的氧化应激。
