Senczyszyn Adrianna, Wallner Renata, Szczesniak Dorota Maria, Łuc Mateusz, Rymaszewska Joanna
Department of Psychiatry, Wroclaw Medical University, Wroclaw, Poland.
Front Psychiatry. 2021 Jun 25;12:649066. doi: 10.3389/fpsyt.2021.649066. eCollection 2021.
Subjective Cognitive Decline (SCD) and Mild Cognitive Impairment (MCI) are common in elderly population, and constitute a high-risk group for progression to dementia. Innovative, complex, and engaging non-pharmacological methods of cognitive stimulation, implementable at this stage, are needed. The aim of the study was to determine the effect of Computerized Cognitive Training (CCT) combined with Whole Body Stimulation (WBC) on cognitive functions of older adults with SCD and MCI. A 9-week single-blind pre/post case control trial was conducted. The study enrolled 84 adults aged 60 or older, allocated to one of two intervention groups: EG; CCT with psychoeducation, EG2; CCT with psychoeducation and 10 WBC sessions, or the control group (CG), which comprised patients receiving usual care. The primary outcome measures were cognitive functions evaluated with MoCA scale and several other neuropsychological tools. Depressive symptoms assessed with the GDS scale constituted the secondary outcome measures. The results show evidence for increased performance in the assessment of general cognitive functioning in both EGs ( ≤ 0.05). Significant improvement was also visible in several cognitive domains, such as verbal fluency (EG1 & EG2), learning ability and immediate memory (EG1 & EG2), delayed memory (EG2), attentional control (EG1), and information processing (EG2) ( ≤ 0.05). However, only in the group with combined interventions (CCT + WBC) the participants presented significantly less depressive symptoms ( ≤ 0.05). The results of the study suggest that CCT, especially in combination with WBC, might be a practical and effective method of improving cognitive performance. Moreover, this combination leads to a reduction of depressive symptoms.
主观认知下降（SCD）和轻度认知障碍（MCI）在老年人群中很常见，并且是发展为痴呆症的高危群体。在此阶段，需要创新、复杂且引人入胜的可实施非药物认知刺激方法。本研究的目的是确定计算机化认知训练（CCT）与全身刺激（WBC）相结合对患有SCD和MCI的老年人认知功能的影响。进行了一项为期9周的单盲前后对照试验。该研究招募了84名60岁及以上的成年人，分为两个干预组之一：EG1；接受CCT并辅以心理教育，EG2；接受CCT并辅以心理教育以及10次WBC治疗，或对照组（CG），该组患者接受常规护理。主要结局指标是用MoCA量表和其他几种神经心理学工具评估的认知功能。用GDS量表评估的抑郁症状构成次要结局指标。结果表明，两个干预组在一般认知功能评估中的表现均有所提高（P≤0.05）。在几个认知领域也有显著改善，如语言流畅性（EG1和EG2）、学习能力和即时记忆（EG1和EG2）、延迟记忆（EG2）、注意力控制（EG1）和信息处理（EG2）（P≤0.05）。然而，只有在联合干预组（CCT+WBC）中，参与者的抑郁症状明显较少（P≤0.05）。研究结果表明，CCT，尤其是与WBC相结合，可能是提高认知表现的一种实用且有效的方法。此外，这种组合还能减轻抑郁症状。
