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膜转运蛋白与信使核糖核蛋白颗粒的热应激依赖性关联具有选择性。

Heat Stress-Dependent Association of Membrane Trafficking Proteins With mRNPs Is Selective.

作者信息

Wolff Heike, Jakoby Marc, Stephan Lisa, Koebke Eva, Hülskamp Martin

机构信息

Cluster of Excellence on Plant Sciences (CEPLAS), Botanical Institute, Cologne University, Cologne, Germany.

Botanical Institute, Biocenter, Cologne University, Cologne, Germany.

出版信息

Front Plant Sci. 2021 Jun 24;12:670499. doi: 10.3389/fpls.2021.670499. eCollection 2021.

DOI:10.3389/fpls.2021.670499
PMID:34249042
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8264791/
Abstract

The Arabidopsis AAA ATPase SKD1 is essential for ESCRT-dependent endosomal sorting by mediating the disassembly of the ESCRTIII complex in an ATP-dependent manner. In this study, we show that SKD1 localizes to messenger ribonucleoprotein complexes upon heat stress. Consistent with this, the interactome of SKD1 revealed differential interactions under normal and stress conditions and included membrane transport proteins as well as proteins associated with RNA metabolism. Localization studies with selected interactome proteins revealed that not only RNA associated proteins but also several ESCRTIII and membrane trafficking proteins were recruited to messenger ribonucleoprotein granules after heat stress.

摘要

拟南芥AAA型ATP酶SKD1通过以ATP依赖的方式介导ESCRTIII复合物的解体，对ESCRT依赖的内体分选至关重要。在本研究中，我们发现热胁迫时SKD1定位于信使核糖核蛋白复合物。与此一致的是，SKD1的相互作用组在正常和胁迫条件下显示出不同的相互作用，包括膜转运蛋白以及与RNA代谢相关的蛋白。对选定的相互作用组蛋白进行的定位研究表明，热胁迫后不仅RNA相关蛋白，而且几种ESCRTIII和膜运输蛋白都被招募到信使核糖核蛋白颗粒中。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e699/8264791/86a0982f63f0/fpls-12-670499-g0009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e699/8264791/7f20b8a269cd/fpls-12-670499-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e699/8264791/f2bab0b1a2b3/fpls-12-670499-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e699/8264791/a23608aa9ba8/fpls-12-670499-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e699/8264791/ade5dcaa2785/fpls-12-670499-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e699/8264791/3fa40793cec5/fpls-12-670499-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e699/8264791/64035d559336/fpls-12-670499-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e699/8264791/7a789bbca759/fpls-12-670499-g0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e699/8264791/8263c0d64de7/fpls-12-670499-g0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e699/8264791/86a0982f63f0/fpls-12-670499-g0009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e699/8264791/7f20b8a269cd/fpls-12-670499-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e699/8264791/f2bab0b1a2b3/fpls-12-670499-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e699/8264791/a23608aa9ba8/fpls-12-670499-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e699/8264791/ade5dcaa2785/fpls-12-670499-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e699/8264791/3fa40793cec5/fpls-12-670499-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e699/8264791/64035d559336/fpls-12-670499-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e699/8264791/7a789bbca759/fpls-12-670499-g0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e699/8264791/8263c0d64de7/fpls-12-670499-g0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e699/8264791/86a0982f63f0/fpls-12-670499-g0009.jpg

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