Rampino Antonio, Falcone Rosa M, Giannuzzi Arianna, Masellis Rita, Antonucci Linda A, Torretta Silvia
Department of Basic Medical Sciences, Neuroscience, and Sense Organs, University of Bari Aldo Moro, 70124 Bari, Italy.
Azienda Ospedaliero-Universitaria Policlinico di Bari, 70124 Bari, Italy.
Clin Pract Epidemiol Ment Health. 2021 May 24;17:31-47. doi: 10.2174/1745017902117010031. eCollection 2021.
Cognitive deficits are core features of Schizophrenia, showing poor response to antipsychotic treatment, therefore non-pharmacological rehabilitative approaches to such a symptom domain need to be identified. However, since not all patients with Schizophrenia exhibit the same cognitive impairment profile, individualized rehabilitative approaches should be set up.
We explored the last five-year literature addressing the issue of cognitive dysfunction response to rehabilitative methodologies in Schizophrenia to identify possible predictors of response and individualized strategies to treat such a dysfunction.
A total of 76 studies were reviewed. Possible predictors of cognitive rehabilitation outcome were identified among patient-specific and approach-specific variables and a general overview of rehabilitative strategies used in the last five years has been depicted. Studies suggest the existence of multifaced and multi-domain variables that could significantly predict pro-cognitive effects of cognitive rehabilitation, which could also be useful for identifying individual-specific rehabilitation trajectories over time.An individualized rehabilitative approach to cognitive impairment in Schizophrenia is possible if taking into account both patient and approach specific predictors of outcomes.
认知缺陷是精神分裂症的核心特征，对抗精神病药物治疗反应不佳，因此需要确定针对这一症状领域的非药物康复方法。然而，由于并非所有精神分裂症患者都表现出相同的认知障碍特征，所以应制定个性化的康复方法。
我们检索了过去五年中关于精神分裂症认知功能障碍对康复方法反应的文献，以确定可能的反应预测因素和治疗这种功能障碍的个性化策略。
共检索到76项研究。在患者特异性和方法特异性变量中确定了认知康复结果的可能预测因素，并描绘了过去五年中使用的康复策略的总体概况。研究表明，存在多方面和多领域的变量，这些变量可以显著预测认知康复的促认知效果，这也有助于确定随时间变化的个体特异性康复轨迹。如果同时考虑患者和方法特异性的结果预测因素，那么针对精神分裂症认知障碍的个性化康复方法是可行的。
