Hajhashemi Valiollah, Sajjadi Seyed Ebrahim, Hasani Maram
Department of Pharmacology and Toxicology and Isfahan Pharmaceutical Sciences Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Department of Pharmacognosy, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran.
Int J Prev Med. 2021 May 15;12:40. doi: 10.4103/ijpvm.IJPVM_550_20. eCollection 2021.
The fruits of Apiaceae family have been widely used in traditional medicine for the treatment of pain and inflammation. In this study, we evaluated the analgesic and anti-inflammatory effects of wild celery () seeds, as a member of the Apiaceae family.
Hydroalcoholic and hexane extracts of seeds were prepared and for the evaluation of analgesic activity, acetic acid, formalin, and hotplate tests in male mice (20-30 g) and for anti-inflammatory assessment carrageenan-induced paw edema in rats and croton oil-induced ear edema in mice were used.
Hydroalcoholic and hexane extracts (100-400 mg/kg) significantly reduced abdominal spasms in the acetic acid test. In the formalin test, the hydroalcoholic extract at doses of 200 and 400 mg/kg reduced the pain of the chronic phase while hexane extract was effective in both acute and chronic phases. In the hot plate test, both extracts were ineffective. In the carrageenan and croton tests, both extracts at a dose of 400 mg/kg significantly reduced edema.
The results revealed the analgesic and anti-inflammatory effects of plant seed extracts. Due to the lack of response of the extracts in the hot plate test, it seems that the plant mainly has a peripheral analgesic effect.
伞形科植物果实已在传统医学中广泛用于治疗疼痛和炎症。在本研究中，我们评估了作为伞形科植物成员的野芹菜种子的镇痛和抗炎作用。
制备种子的水醇提取物和己烷提取物，用于评估雄性小鼠（20 - 30克）的镇痛活性，采用乙酸、福尔马林和热板试验；用于抗炎评估，采用角叉菜胶诱导的大鼠足肿胀和巴豆油诱导的小鼠耳肿胀试验。
水醇提取物和己烷提取物（100 - 400毫克/千克）在乙酸试验中显著减少腹部痉挛。在福尔马林试验中，200和400毫克/千克剂量的水醇提取物减轻了慢性期疼痛，而己烷提取物在急性期和慢性期均有效。在热板试验中，两种提取物均无效。在角叉菜胶和巴豆试验中，400毫克/千克剂量的两种提取物均显著减轻肿胀。
结果揭示了植物种子提取物的镇痛和抗炎作用。由于提取物在热板试验中无反应，似乎该植物主要具有外周镇痛作用。
