Bapatla Neha, Ramoutar Uma D, Sharma Natasha, Ramoutar Anjali, Ortega Valentina L, Goorachan Anita, Haffizulla Farzanna
College of Allopathic Medicine, Nova Southeastern University Dr. Kiran C. Patel College of Allopathic Medicine, Davie, USA.
Medicine, St. George's University School of Medicine, True Blue, GRD.
Cureus. 2021 Jun 1;13(6):e15375. doi: 10.7759/cureus.15375. eCollection 2021 Jun.
At the beginning of the 20th century, there was a shift in disease patterns from that of communicable disease to noncommunicable disease (NCD). As a result, cardiovascular disease (CVD) has emerged as a leading cause of morbidity and mortality worldwide. Its incidence and effect on various populations at a molecular level as well as clinical implications have been heavily studied; however, its role in morbidity and mortality in the Indo-Caribbean population is often overlooked. The Caribbean diaspora is a vibrant and heterogeneous culture, encompassing individuals with ancestries from across the world including the Indian subcontinent and Africa. Abundant research is consistently conducted on these populations, but limited research exists on how the interplay between genetics and environment translates to the manifestation of various diseases in the Indo-Caribbean population. This scoping review aims to identify and assess the current literature within the past 10 years conducted on CVD in Indo-Caribbeans in order to gain a thorough understanding of disease and management to improve health outcomes. Additionally, this review aimed to identify gaps in research that require further study to gain a better understanding of relevant variables affecting disease outcomes in the Indo-Caribbean population. Multiple health databases were queried, and the initial search yielded over 3,000 results. However, after screening with the inclusion and exclusion criteria established, the final search included less than 1% of the papers initially searched. This search yielded data that included treatment and management of myocardial infarction, hypertension, and atherosclerosis, but notably did not yield papers that discussed the relationship between social determinants of health and CVD in Indo-Caribbeans. Florida and New York are prominent states that have robust Indo-Caribbean populations; the lack of research renders these states vulnerable to improving health outcomes in these patients. The authors call for increased focus on this population in research studies and efforts to improve the quality of the data collected through stratification by ethnicity. Robust data may allow for improvement in the treatment and management of CVD in Indo-Caribbeans, which offers a more proactive rather than reactive approach to decreasing morbidity and mortality.
20世纪初,疾病模式从传染病转向了非传染性疾病(NCD)。结果,心血管疾病(CVD)已成为全球发病和死亡的主要原因。人们对其发病率、在分子水平上对不同人群的影响以及临床意义进行了大量研究;然而,其在印度裔加勒比人群发病和死亡中的作用常常被忽视。加勒比侨民是一种充满活力且多元的文化群体,包括来自世界各地(包括印度次大陆和非洲)有祖先渊源的个人。针对这些人群进行了大量持续的研究,但关于基因与环境的相互作用如何转化为印度裔加勒比人群中各种疾病的表现的研究却很有限。本综述旨在识别和评估过去10年中关于印度裔加勒比人心血管疾病的现有文献,以便全面了解疾病及管理方法,从而改善健康结果。此外,本综述旨在找出研究中的空白,这些空白需要进一步研究,以更好地理解影响印度裔加勒比人群疾病结果的相关变量。查询了多个健康数据库,初步搜索产生了3000多条结果。然而,在根据既定的纳入和排除标准进行筛选后,最终纳入的论文不到最初搜索论文的1%。这次搜索得到的数据包括心肌梗死、高血压和动脉粥样硬化的治疗与管理,但值得注意的是,没有找到讨论健康的社会决定因素与印度裔加勒比人心血管疾病之间关系的论文。佛罗里达州和纽约州是拥有大量印度裔加勒比人群的主要州;研究的缺乏使这些州在改善这些患者的健康结果方面面临挑战。作者呼吁在研究中更多地关注这一人群,并努力通过按种族分层来提高所收集数据的质量。可靠的数据可能有助于改善印度裔加勒比人心血管疾病的治疗与管理,从而提供一种更积极主动而非被动应对的方法来降低发病率和死亡率。