Akhunzada Hawwa A, Rehman Hassan, Tariq Nabeel, Arif Mohammad Ali, Niazi Rauf
Internal Medicine, Shaheed Zulfiqar Ali Bhutto Medical University/Pakistan Institute of Medical Sciences, Islamabad, PAK.
Internal Medicine and Endocrinology/Diabetology, Shaheed Zulfiqar Ali Bhutto Medical University/Pakistan Institute of Medical Sciences, Islamabad, PAK.
Cureus. 2021 Jun 2;13(6):e15385. doi: 10.7759/cureus.15385. eCollection 2021 Jun.
Enteric fever is a multisystem illness caused by Typhi and Paratyphi, and it is associated with a spectrum of conditions ranging from minor cases of diarrhea and low-grade fever to a potentially fatal illness that can lead to gastrointestinal (GI) perforation, hemorrhage, central nervous system (CNS) involvement. Neuroleptic malignant syndrome (NMS) is predominantly described as an idiosyncratic reaction to neuroleptic medications. However, it has also been associated with a variety of drugs that reduce dopaminergic activity. In this report, we present the case of a young woman who had enteric fever and was prescribed IV ceftriaxone and domperidone. She subsequently developed NMS secondary to domperidone. We highlight the challenges faced when dealing with two potentially lethal medical conditions presenting concurrently and their overlapping symptoms. The patient was treated for both of the conditions and recovered completely.
伤寒是由伤寒杆菌和副伤寒杆菌引起的多系统疾病，它与一系列病症相关，从轻症腹泻和低热到可能致命的疾病，后者可导致胃肠道穿孔、出血、中枢神经系统受累。抗精神病药物恶性综合征（NMS）主要被描述为对抗精神病药物的特异反应。然而，它也与多种降低多巴胺能活性的药物有关。在本报告中，我们介绍了一名患有伤寒的年轻女性病例，她接受了静脉注射头孢曲松和多潘立酮治疗。随后，她因多潘立酮继发了NMS。我们强调了同时处理两种潜在致命医疗状况及其重叠症状时所面临的挑战。患者针对这两种病症进行了治疗并完全康复。
