质粒在不依赖调理素的金黄色葡萄球菌与白细胞相互作用中的作用。

The role of plasmids in opsonin-independent Staphylococcus aureus-leukocyte interactions.

作者信息

Garliński P, Młynarczyk G, Roszkowski W, Pulverer G, Jeljaszewicz J

机构信息

Department of Immunology, National Tuberculosis Research Institute, Warsaw, Poland.

出版信息

Zentralbl Bakteriol Mikrobiol Hyg A. 1987 Aug;266(1-2):43-51. doi: 10.1016/s0176-6724(87)80019-6.

DOI:10.1016/s0176-6724(87)80019-6

PMID:3425035

Abstract

The opsonin-independent phagocytic and bactericidal activity of human polymorphonuclear leukocytes stimulated by two Staphylococcus aureus strains and their variants with differing plasmid patterns was investigated. Interactions between staphylococci and phagocytes were evaluated by chemiluminescence and intracellular killing tests. The results obtained indicate that the presence or absence of certain plasmids can modify staphylococcal phagocytosis and their susceptibility to intracellular killing. Pretreatment of the strains investigated with subinhibitory concentrations of mezlocillin and ofloxacin (10% MIC) influenced these parameters, too.

摘要

研究了两种金黄色葡萄球菌菌株及其具有不同质粒图谱的变体刺激人多形核白细胞的不依赖调理素的吞噬和杀菌活性。通过化学发光和细胞内杀伤试验评估葡萄球菌与吞噬细胞之间的相互作用。获得的结果表明，某些质粒的存在与否可改变葡萄球菌的吞噬作用及其对细胞内杀伤的敏感性。用亚抑制浓度的美洛西林和氧氟沙星（10% MIC）对所研究的菌株进行预处理也影响了这些参数。