Peterson P K, Verhoef J, Sabath L D, Quie P G
Infect Immun. 1976 Aug;14(2):496-501. doi: 10.1128/iai.14.2.496-501.1976.
Extracellular and bacterial factors that influence the phagocytosis and killing of staphylococci by human polymorphonuclear leukocytes have been studied. Staphylococcus epidermidis strains were, in general, more rapidly phagocytized than were S. aureus strains. However, two strains of S. epidermidis had a very slow rate of ingestion. Although the rate of phagocytosis of S. aureus Wood 46 was greater than that of S. aureus 502A, the Wood 46 strain was more difficult to kill. Serum was essential for phagocytosis of both S. aureus and S. epidermidis. The opsonic titer of pooled serum was similar for S. aureus and S. epidermidis. In normal pooled serum, heat-labile factors were more important for effective phagocytosis than they were in immune serum. Although a saturation point for ingestion was reached, the percentage of ingested bacteria that remained alive within the leukocyte remained relatively fixed. Heat-killed and live staphylococci were igested in a similar fashion. The rate of phagocytosis was greatly reduced at 41 degrees C.
对影响人类多形核白细胞吞噬和杀灭葡萄球菌的细胞外及细菌因素进行了研究。一般来说，表皮葡萄球菌菌株比金黄色葡萄球菌菌株更易被快速吞噬。然而，有两株表皮葡萄球菌的摄取速率非常缓慢。尽管金黄色葡萄球菌伍德46株的吞噬速率大于金黄色葡萄球菌502A株，但伍德46株更难被杀死。血清对金黄色葡萄球菌和表皮葡萄球菌的吞噬作用至关重要。混合血清的调理素效价对金黄色葡萄球菌和表皮葡萄球菌而言相似。在正常混合血清中，热不稳定因子对有效吞噬作用比在免疫血清中更重要。尽管达到了摄取的饱和点，但白细胞内仍存活的摄取细菌的百分比保持相对固定。热杀死的和活的葡萄球菌以相似的方式被吞噬。在41摄氏度时，吞噬速率大大降低。
