Apaja-Sarkkinen M, Väänänen K, Curran S, Siponen P, Autio-Harmainen H
Department of Pathology, Keski-Pohjanmaa Central Hospital, Kokkola, Finland.
Acta Cytol. 1987 Nov-Dec;31(6):769-73.
A cartilaginous tumor of the cervical spine in a 31-year-old man is described, with discussion of the differential diagnostic problems both in aspiration biopsy cytology and in histopathology. The tumor mass caused nasopharyngeal swelling and infiltrated the base of the skull and the spinal canal. Aspiration biopsy cytology of the tumor demonstrated mostly papillary epithelial groupings, causing differential diagnostic problems with thyroid and salivary gland carcinomas. Most of the tumor mass was resected, with postoperative radiation performed. Immunohistochemical staining for type II procollagen on the histologic sections confirmed the presence of cartilage. The epithelial components of the tumor appeared to be cytokeratin-positive. Immunohistochemical staining for laminin and type IV collagen revealed positivity only in the blood vessel walls. The diagnosis of cervical chordoma was established by the histologic examination. The patient is without symptoms two years after removal of the tumor.
本文描述了一名31岁男性颈椎的软骨肿瘤，并讨论了细针穿刺活检细胞学和组织病理学中的鉴别诊断问题。肿瘤肿块导致鼻咽部肿胀，并侵犯了颅底和椎管。肿瘤的细针穿刺活检细胞学显示主要为乳头状上皮细胞团，这给甲状腺癌和唾液腺癌的鉴别诊断带来了问题。大部分肿瘤肿块被切除，并进行了术后放疗。组织学切片上II型前胶原的免疫组化染色证实了软骨的存在。肿瘤的上皮成分似乎细胞角蛋白呈阳性。层粘连蛋白和IV型胶原的免疫组化染色仅在血管壁呈阳性。通过组织学检查确诊为颈椎脊索瘤。肿瘤切除两年后患者无症状。
