（±）-Codonopiloneolignanin A 的全合成。

Total Synthesis of (±)-Codonopiloneolignanin A.

机构信息

Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry & Pharmacy, Northwest A&F University, Yangling, Shaanxi 712100, China.

Department of Chemistry, Changzhi University, Changzhi 046011, Shanxi China.

出版信息

Org Lett. 2021 Aug 6;23(15):5684-5688. doi: 10.1021/acs.orglett.1c01803. Epub 2021 Jul 12.

DOI:10.1021/acs.orglett.1c01803

PMID:34251830

Abstract

An intramolecular formal [3 + 2] cationic cycloaddition between benzylic carbocation and styrene was developed for the total synthesis of codonopiloneolignanin A. Further study shows benzocycloheptene as a good substrate for 1,3-dipolar cycloaddition, and a model study toward cephalocyclidine A skeleton was reported.

摘要

发展了一种苄基碳正离子与苯乙烯之间的分子内[3+2]阳离子环加成反应，用于 codonopiloneolignanin A 的全合成。进一步的研究表明，苯并环庚烯是 1,3-偶极环加成的良好底物，并报道了朝向cephalocyclidine A 骨架的模型研究。