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Total synthesis of 6'-hydroxyjusticidin A.

作者信息

Xiong Lu, Bi Ming-Gang, Wu Song, Tong Yuan-Feng

机构信息

State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Department of New Drug Research and Development, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.

出版信息

J Asian Nat Prod Res. 2012;14(4):322-6. doi: 10.1080/10286020.2011.653561.

DOI:10.1080/10286020.2011.653561
PMID:22375869
Abstract

The first total synthesis of 6'-hydroxyjusticidin A, isolated from Justicia procumbens L. with good inhibitory activity against cancer cells, has been accomplished. The structure was confirmed by ¹H NMR, ¹³C NMR, and HR-ESI-MS. The key steps involved a Diels-Alder cycloaddition reaction and a reduction in NaBH₄.

摘要

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