Evaluation of electrocardiographic ventricular repolarization parameters in extreme obesity.

BACKGROUND AND OBJECTIVES

The risk of sudden death and cardiac arrhythmia increases in morbidly obese patients. We aimed to evaluate the marker of arrhythmias such as Tp-e/QT, Tp-e/QTc, Tp-e/JT and Tp-e/JTc ratios in extreme obesity.

METHODS

The study included 41 extremely obese patients and 41 control subjects. QTmax, QTmin, QRS, JT and Tp-e intervals were measured od 12‑lead electrocardiographies. In addition, Tp-e/QT, Tp-e/QTc, Tp-e/JT and Tp-e/JTc rates and QTc, cQTd and JTc intervals were calculated.

RESULTS

Tp-e interval (79.2 ± 9.7 ms (milisecond) vs. 68.6 ± 8.1, p < 0.001), QTc interval (395.9 ± 18.8 vs. 377.9 ± 19.3 ms, p < 0.001), JTc interval (317.1 ± 27.0 vs. 297.4 ± 23.2 ms, p = 0.001), Tp-e/QT ratio (0.22 ± 0.03vs. 0.19 ± 0.02, p < 0.001), Tp-e/QTc ratio (0.20 ± 0.26vs. 0.18 ± 0.02, p = 0.001), Tp-e/JT ratio (0.29 ± 0.04 vs. 0.25 ± 0.03, p < 0.001), TPe/JTc ratio (0.25 ± 0.04 vs. 0.23 ± 0.03, p = 0.018), QTd (32.8 ± 10 vs.15 ± 6.4 ms, p < 0.001) and cQTd (70.0 ± 30.1 vs. 31.3 ± 22.4 ms, p < 0.001) were significantly higher in obese patients.

CONCLUSION

Compared to healthy subjects potential ECG repolarization predictors were significantly increased in extremely obese patients.