Department of Chemistry, Birla Institute of Technology & Science, Pilani, Hyderabad Campus, Jawahar Nagar, Kapra Mandal, Hyderabad, 500078, Telangana, India.
Medicinal Chemistry Research Laboratory, Department of Pharmacy, Birla Institute of Technology & Science Pilani, Pilani Campus, Pilani, 333031, Rajasthan, India.
Future Med Chem. 2021 Sep;13(18):1591-1618. doi: 10.4155/fmc-2021-0086. Epub 2021 Jul 14.
Among all nitrogen-containing heterocycles, the 1,8-naphthyridine scaffold has recently gained an immense amount of curiosity from numerous researchers across fields of medicinal chemistry and drug discovery. This new attention can be ascribed to its versatility of synthesis, its reactiveness and the variety of biological activities it has exhibited. Over the past half-decade, numerous diverse biological evaluations have been conducted on 1,8-naphthyridine and its derivatives in a quest to unravel novel pharmacological facets to this scaffold. Its potency to treat neurodegenerative and immunomodulatory disorders, along with its anti-HIV, antidepressant and antioxidant properties, has enticed researchers to look beyond its broad-spectrum activities, providing further scope for exploration. This review is a consolidated update of previous works on 1,8-naphthyridines and their analogs, focusing on the past 5 years.
在所有含氮杂环中，1,8-萘啶骨架最近引起了众多药物化学和药物发现领域研究人员的极大兴趣。这种新的关注可以归因于其合成的多功能性、反应性以及它所表现出的各种生物活性。在过去的五年中，对 1,8-萘啶及其衍生物进行了大量不同的生物评价，以揭示该骨架的新的药理学方面。它在治疗神经退行性和免疫调节紊乱方面的功效，以及其抗 HIV、抗抑郁和抗氧化特性，吸引了研究人员超越其广谱活性，为进一步探索提供了更多的空间。本文综述了过去 5 年关于 1,8-萘啶及其类似物的研究工作，对其进行了总结。
