葡萄糖是否是肿瘤逃避的替罪羊？
Is glucose the scapegoat for tumor evasion?
机构信息
Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH, USA; Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
出版信息
Cancer Cell. 2021 Jul 12;39(7):907-909. doi: 10.1016/j.ccell.2021.06.006.
Tumor cells undergo rapid aerobic glycolysis to fuel growth and proliferation. A recent finding in Nature reveals that tumor-infiltrating myeloid cells demonstrate greater capacity for glucose uptake than tumor cells and consume significant amounts within the tumor milieu. Unexpectedly, tumor cells account for the highest glutamine utilization in the tumor microenvironment.
肿瘤细胞通过快速的有氧糖酵解为生长和增殖提供燃料。最近在《自然》杂志上的一项发现表明，肿瘤浸润的髓样细胞表现出比肿瘤细胞更高的葡萄糖摄取能力，并在肿瘤微环境中消耗大量的葡萄糖。出人意料的是，肿瘤细胞在肿瘤微环境中利用谷氨酰胺的效率最高。
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