Huuhka Milla, Turunen Aaro
Department of Oral and Maxillofacial Diseases, Turku University Hospital, Turku, Finland.
Department of Oral and Maxillofacial Surgery, Institute of Dentistry, University of Turku, Turku, Finland.
Case Rep Dent. 2021 Jun 23;2021:5571649. doi: 10.1155/2021/5571649. eCollection 2021.
Fanconi anemia (FA) is a rare autosomal recessive genetic disorder characterized by different types of malformations, skin lesions, bone marrow failure, and increased risk for both hematological malignancies and solid tumors, especially head and neck squamous cell carcinomas (HNSCC). FA patients may also display a low tolerance to oncologic treatments. The authors present a case of mandibular squamous cell carcinoma in a young FA patient. Because of the aggressive nature of the SCC and complex treatment options, we recommend a strict lifelong follow-up for all FA patients to detect early changes in the oral mucosa.
范可尼贫血（FA）是一种罕见的常染色体隐性遗传病，其特征为出现不同类型的畸形、皮肤病变、骨髓衰竭，以及血液系统恶性肿瘤和实体瘤（尤其是头颈部鳞状细胞癌，HNSCC）的发病风险增加。FA患者对肿瘤治疗的耐受性也可能较低。作者报告了一例年轻FA患者发生下颌鳞状细胞癌的病例。鉴于鳞状细胞癌的侵袭性及复杂的治疗选择，我们建议对所有FA患者进行严格的终身随访，以检测口腔黏膜的早期变化。
