Genomic and proteomic comparisons of bacteriocins in probiotic species and and inhibitory ability of MG 1655.

Bacteriocins are a large family of bacterial peptides or proteins, ribosomally synthesized with antimicrobial activity against other bacteria. We investigated and compared the genomes and proteomes of 12 and 46 species for bacteriocins using NCBI-Genome, UniProt-Proteome, Bactibase, and BAGL4 databases. Selected species were examined for bile salt resistance, acid and pH resistance, pepsin and trypsin enzyme resistance, and antibiotic resistance. Also, the antimicrobial activity of selected species was evaluated against MG 1655. Results showed that species have more diversity and abundance of bacteriocin compared to species. Notably and had the highest pathogen inhibition; respectively. Therefore, a combination of these species can be suggested as a biochemical and safe solution to control gastrointestinal pathogens and suitable alternatives to antibiotics and chemicals in food technology.