Darvishi Nasrin, Fard Najaf Allahyari, Sadrnia Maryam
Payame Noor University (PNU), National Institute of Genetic Engineering and Biotechnology, Iran.
National Institute of Genetic Engineering and Biotechnology (NIGEB), Iran.
Biotechnol Rep (Amst). 2021 Jun 22;31:e00654. doi: 10.1016/j.btre.2021.e00654. eCollection 2021 Sep.
Bacteriocins are a large family of bacterial peptides or proteins, ribosomally synthesized with antimicrobial activity against other bacteria. We investigated and compared the genomes and proteomes of 12 and 46 species for bacteriocins using NCBI-Genome, UniProt-Proteome, Bactibase, and BAGL4 databases. Selected species were examined for bile salt resistance, acid and pH resistance, pepsin and trypsin enzyme resistance, and antibiotic resistance. Also, the antimicrobial activity of selected species was evaluated against MG 1655. Results showed that species have more diversity and abundance of bacteriocin compared to species. Notably and had the highest pathogen inhibition; respectively. Therefore, a combination of these species can be suggested as a biochemical and safe solution to control gastrointestinal pathogens and suitable alternatives to antibiotics and chemicals in food technology.
细菌素是一大类细菌肽或蛋白质，通过核糖体合成，对其他细菌具有抗菌活性。我们使用NCBI-基因组、UniProt-蛋白质组、细菌素数据库和BAGL4数据库，对12种和46种细菌的基因组和蛋白质组进行了研究和比较，以寻找细菌素。对选定的细菌进行了耐胆盐、耐酸和耐pH值、耐胃蛋白酶和胰蛋白酶以及抗生素耐药性的检测。此外，还评估了选定细菌对MG 1655的抗菌活性。结果表明，与[未提及的细菌种类]相比，[提及的细菌种类]具有更多样化和丰富的细菌素。值得注意的是，[具体细菌种类1]和[具体细菌种类2]分别具有最高的病原体抑制率。因此，可以建议将这[提及的细菌种类数量]种细菌组合起来，作为控制胃肠道病原体的生化安全解决方案，以及食品技术中抗生素和化学物质的合适替代品。
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