基于 16S rRNA 基因测序的慢性牙周炎伴和不伴牙龈侵蚀性口腔扁平苔藓患者龈下微生物组的比较分析。

Comparative Analyses of the Subgingival Microbiome in Chronic Periodontitis Patients with and without Gingival Erosive Oral Lichen Planus Based on 16S rRNA Gene Sequencing.

机构信息

Department of Periodontology, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, National Clinical Research Center for Oral Diseases, Shanghai, China.

出版信息

Biomed Res Int. 2021 Jun 27;2021:9995225. doi: 10.1155/2021/9995225. eCollection 2021.

DOI:10.1155/2021/9995225

PMID:34258290

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8257348/

Abstract

The aim of the study was to compare the microbiota composition and bacterial diversity of subgingival plaque in chronic periodontitis patients with and without gingival erosive oral lichen planus. The subgingival plaque samples of 20 chronic periodontitis patients with gingival erosive oral lichen planus (CP-OLP group) and 19 chronic periodontitis patients without gingival erosive oral lichen planus (CP group) were analyzed by 16S rRNA gene high-throughput sequencing. Compared with the CP group, the richness and diversity of subgingival plaque microflora in the CP-OLP group decreased significantly. There were some differences between the two groups in the composition of microflora on the levels of phylum and genus. Distributions of and in the CP-OLP group were significantly lower than those in the CP group. The dominant genera in CP-OLP group were and . These results indicated that gingival erosive oral lichen planus may influence the structure and proportion of subgingival plaque microflora.

摘要

本研究旨在比较伴或不伴口腔糜烂性扁平苔藓的慢性牙周炎患者龈下菌斑的微生物组成和细菌多样性。通过 16S rRNA 基因高通量测序分析了 20 例伴口腔糜烂性扁平苔藓的慢性牙周炎患者（CP-OLP 组）和 19 例不伴口腔糜烂性扁平苔藓的慢性牙周炎患者（CP 组）的龈下菌斑样本。与 CP 组相比，CP-OLP 组龈下菌斑微生物区系的丰富度和多样性显著降低。在门和属水平上，两组微生物区系的组成存在一些差异。在 CP-OLP 组中，和的分布明显低于 CP 组。CP-OLP 组的优势属为和。这些结果表明，口腔糜烂性扁平苔藓可能影响龈下菌斑微生物区系的结构和比例。