Rogers Ralph, Ehmann Sarah, Tew William P, Broach Vance
Gynecology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Obstetrics and Gynecology, Mercer University Memorial Health Medical Center, Savannah, GA, USA.
Gynecol Oncol Rep. 2021 Jun 23;37:100818. doi: 10.1016/j.gore.2021.100818. eCollection 2021 Aug.
We present a unique case of high-grade serous carcinoma isolated to the spleen at the time of diagnosis, without any tumor present in the ovary, fallopian tubes, omentum or uterus, which was pathologically consistent with metastatic Mullerian carcinoma. Tumor sequencing with the MSK-IMPACT (Memorial Sloan Kettering-Integrated Mutation Profiling of Actionable Cancer Targets) multigene tumor panel test was performed, which revealed somatic mutations in PALB2 and in ARID1, as well as a TP53 hotspot mutation.
我们报告了一例独特的病例，诊断时高级别浆液性癌仅局限于脾脏，卵巢、输卵管、大网膜或子宫均未发现任何肿瘤，病理检查结果与转移性苗勒管癌相符。采用MSK-IMPACT（纪念斯隆凯特琳癌症中心可操作癌症靶点综合突变分析）多基因肿瘤检测板进行肿瘤测序，结果显示PALB2和ARID1存在体细胞突变，以及TP53热点突变。
