Liu Bing, Zhu Jiaming, Zhou Qin, Yu Dongyou
College of Animal Sciences, Zhejiang University, Hangzhou, 310058, China.
State Key Laboratory of Food Science and Technology, and Synergetic Innovation Center of Food Safety and Nutrition, Jiangnan University, Wuxi, 214122, China.
Anim Nutr. 2021 Jun;7(2):576-586. doi: 10.1016/j.aninu.2020.08.009. Epub 2021 Feb 27.
Sodium sulfate (NaSO) is a readily available chlorine-free source of sodium, which could be used to reduce sodium chloride to maintain the ratio between chlorine and sodium in poultry diets. Dietary supplementation with excessive levels of NaSO might be detrimental to bird's health and performance. A subchronic study was carried out to investigate the potential adverse effects of an accidental oversupply of NaSO in the diets of laying hens. Four hundred and fifty 21-week-old Hy-Line White layers were randomly assigned to 5 treatments with 6 replicates. The birds were fed diets supplemented with 0 (control), 0.3%, 0.6%, 1.5%, and 3.0% NaSO for 8 weeks. Laying performance, egg quality parameters, clinical blood parameters, histopathology, intestinal barrier functions, and intestinal microflora composition were measured. No clinical signs of intoxication or mortality were observed during the experimental period. The results of this study showed that the optimal levels of NaSO (0.3% to 0.6%) significantly improved the laying rates, average daily egg mass, and eggshell quality of hens compared to the control ( < 0.05). However, 3.0% NaSO produced negative effects on laying performance, eggshell quality, blood biochemistry, and particularly on liver and kidney pathology, and intestinal morphology and barrier functions compared with the controls. Although minor changes were observed in clinical blood parameters of hens receiving 1.5% NaSO, these were not considered to be of toxicological significance due to the absence of any organ pathological changes in hens. In conclusion, our results indicated that a NaSO concentration of 1.5% was non-deleterious to laying hens after a daily administration for 56 d, namely that dietary supplementation of up to 5 times the maximum recommended dose is safely tolerated by laying hens.
硫酸钠（Na₂SO₄）是一种易于获取的无氯钠源，可用于减少氯化钠的用量，以维持家禽日粮中氯与钠的比例。日粮中过量添加硫酸钠可能对家禽的健康和生产性能产生不利影响。本研究开展了一项亚慢性试验，以调查蛋鸡日粮中意外过量供应硫酸钠的潜在不良影响。将450只21周龄的海兰白蛋鸡随机分为5组，每组6个重复。给这些蛋鸡饲喂添加了0（对照）、0.3%、0.6%、1.5%和3.0%硫酸钠的日粮，持续8周。测定了产蛋性能、蛋品质参数、临床血液参数、组织病理学、肠道屏障功能和肠道微生物群落组成。在试验期间未观察到中毒的临床症状或死亡情况。本研究结果表明，与对照组相比，硫酸钠的最佳添加水平（0.3%至0.6%）显著提高了蛋鸡的产蛋率、平均日产蛋量和蛋壳质量（P＜0.05）。然而，与对照组相比，3.0%的硫酸钠对产蛋性能、蛋壳质量、血液生化指标产生了负面影响，尤其对肝脏和肾脏病理学以及肠道形态和屏障功能产生了负面影响。尽管在接受1.5%硫酸钠的蛋鸡临床血液参数中观察到了微小变化，但由于蛋鸡未出现任何器官病理变化，这些变化不被认为具有毒理学意义。总之，我们的结果表明，每日给予56天1.5%的硫酸钠浓度对蛋鸡无害，即蛋鸡能够安全耐受日粮中高达最大推荐剂量5倍的添加量。
