Ghaem A
Service de Physiologie, Hôpital Lariboisière, Paris, France.
Allergy. 1987 Nov;42(8):626-30. doi: 10.1111/j.1398-9995.1987.tb00394.x.
The preventive effect of a nasally administered single dose of the dipeptide N-acetyl-aspartyl-glutamate (NAAGA) on pollen-induced early nasal reaction as measured by rhinomanometry and symptomatology was investigated in a double-blind cross-over placebo controlled study in 18 patients with nasal sensitization to grass pollen. Mean nasal airways resistance at 20, 40, and 60 min post challenge was, respectively, 33%, 37% (P = 0.03) and 27% less after NAAGA than after placebo administration in the same patients. In contrast, no significant effect on sneeze count and rhinorrhoea was found.
在一项针对18名对草花粉过敏的患者的双盲交叉安慰剂对照研究中，通过鼻阻力测量法和症状学研究了经鼻单次给药二肽N-乙酰天冬氨酰谷氨酸（NAAGA）对花粉诱导的早期鼻反应的预防作用。在相同患者中，激发后20、40和60分钟时，NAAGA给药组的平均鼻气道阻力分别比安慰剂给药组低33%、37%（P = 0.03）和27%。相比之下，未发现对喷嚏次数和鼻漏有显著影响。
