Western Parana State University, Universidade Estadual Do Oeste Do Paraná - UNIOESTE), University Street, 1619, Cascavel, PR, CEP: 85819-110, Brazil.
Lasers Med Sci. 2022 Mar;37(2):701-721. doi: 10.1007/s10103-021-03372-4. Epub 2021 Jul 14.
The aim of this scoping review was to assess the extent of the literature on the use of LED therapy to treat synovial joint disorders. The JBI methodology for scoping reviews was followed. The databases used were PUBMED, EMBASE, Scopus, Web of Science, LILACS, PEDro, Cochrane Database, Google Scholar and ProQuest. To be included, studies should have used LED as therapy, and include at least one measure related to the structures of any synovial joint. The search strategy included all keywords and indexed terms identified in the articles. Studies in any language and in any year, whether published or not, were included. The analysis of the studies was carried out by two independent reviewers. Data were extracted from articles using a data extraction tool developed by the reviewers. After carrying out the definitive search and selection, 47 publications were included: 15 clinical trials, 8 clinical protocols, 12 animal studies, 4 in vitro studies and 8 reviews on the topic. Studies have shown great variability from the device and number of diodes used, to the parameters and dosimetry chosen. Some positive effects were observed: on cell proliferation (in vitro); on anti-inflammatory biomarkers (murine models) and on pain scale (clinical trials - TMD). Although, the cause of non-significant results in clinical trials was rarely discussed: depth of penetration, dosimetry, follow-up time? Thus, future studies should focus on answering more elementary aspects about the LED effect when used alone in different synovial joints.
本系统评价的目的是评估使用 LED 疗法治疗滑膜关节疾病的文献范围。采用 JBI 方法进行系统评价。使用的数据库有 PUBMED、EMBASE、Scopus、Web of Science、LILACS、PEDro、Cochrane 数据库、Google Scholar 和 ProQuest。纳入标准为：使用 LED 作为治疗方法，且至少包含一项与任何滑膜关节结构相关的测量指标的研究。检索策略包括在文章中确定的所有关键词和索引术语。纳入了所有语言和年份的研究，无论是否发表。研究的分析由两位独立的审查员进行。使用审查员开发的数据提取工具从文章中提取数据。在进行了最终搜索和选择后，共纳入 47 篇文献：15 项临床试验、8 项临床方案、12 项动物研究、4 项体外研究和 8 项关于该主题的综述。研究结果显示，从使用的设备和二极管数量、选择的参数和剂量等方面存在很大的差异。观察到一些积极的效果：体外细胞增殖；抗炎生物标志物（鼠模型）和疼痛量表（临床试验 - TMD）。然而，临床试验中无显著结果的原因很少被讨论：穿透深度、剂量学、随访时间？因此，未来的研究应该集中在回答关于 LED 单独用于不同滑膜关节的更基本的影响方面。
