植物成分作为抗登革热药物发现的先导化合物。

Phytoconstituents as Lead Compounds for Anti-Dengue Drug Discovery.

机构信息

Department of Pharmacognosy, Faculty of Pharmacy, M. S. Ramaiah University of Applied Sciences, Bangalore, Karnataka, India.

Department of Biotechnology, Faculty of Life and Allied Health Sciences, M. S. Ramaiah University of Applied Sciences, Bangalore, Karnataka, India.

出版信息

Adv Exp Med Biol. 2021;1322:159-193. doi: 10.1007/978-981-16-0267-2_7.

DOI:10.1007/978-981-16-0267-2_7

PMID:34258741

Abstract

Dengue is an arthropod-borne viral disease common in subtropical and tropical regions. The widespread use of traditional medicines in these regions for dengue fever (DF) has encouraged researchers to explore the therapeutic effect of herbs and their phytochemicals in dengue infection. Phytochemicals such as quercetin, baicalein, luteolin, oxindole alkaloids, celastrol and geraniin have shown significant inhibition of dengue virus in vitro. Many phytoconstituents have better selectivity index supporting their safety profile for future development. However, in vivo studies supporting therapeutic potency for these active phytoconstituents are limited. There is a need for studies translating anti-dengue profile of active phytoconstituents to find successful anti-dengue compounds.

摘要

登革热是一种虫媒病毒性疾病，常见于亚热带和热带地区。在这些地区，传统药物被广泛用于治疗登革热（DF），这促使研究人员探索草药及其植物化学物质在登革热感染中的治疗效果。植物化学物质，如槲皮素、黄芩素、木樨草素、吲哚生物碱、雷公藤红素和石榴素，已显示出对体外登革病毒有显著的抑制作用。许多植物成分具有更好的选择性指数，支持它们具有未来开发的安全性。然而，支持这些活性植物成分治疗功效的体内研究是有限的。因此，需要进行研究，将活性植物成分的抗登革热特性转化为寻找成功的抗登革热化合物。