Department of Kinesiology and Health Education, University of Texas at Austin, Austin, Texas.
Department of Physiology and Anatomy, University of North Texas Health Science Center, Fort Worth, Texas.
Am J Physiol Regul Integr Comp Physiol. 2021 Aug 1;321(2):R273-R278. doi: 10.1152/ajpregu.00147.2021. Epub 2021 Jul 14.
Prior data suggest that, relative to the early follicular phase, women in the late follicular phase are protected against endothelial ischemia-reperfusion (I/R) injury when estradiol concentrations are highest. In addition, endothelial I/R injury is consistently observed in men with naturally low endogenous estradiol concentrations that are similar to those of women in the early follicular phase. Therefore, the purpose of this study was to determine whether the vasodeleterious effect of I/R injury differs between women in the early follicular phase of the menstrual cycle and age-matched men. We tested the hypothesis that I/R injury would attenuate endothelium-dependent vasodilation to the same extent in women and age-matched men with similar circulating estradiol concentrations. Endothelium-dependent vasodilation was assessed via brachial artery flow-mediated dilation (duplex ultrasound) in young healthy men ( = 22) and women ( = 12) before (pre-I/R) and immediately after (post-I/R) I/R injury, which was induced via 20 min of arm circulatory arrest followed by 20-min reperfusion. Serum estradiol concentrations did not differ between sexes (men 115.0 ± 33.9 pg·mL vs. women 90.5 ± 40.8 pg·mL; = 0.2). The magnitude by which I/R injury attenuated endothelium-dependent vasodilation did not differ between men (pre-I/R 5.4 ± 2.4% vs. post-I/R 3.0 ± 2.7%) and women (pre-I/R 6.1 ± 2.8% vs. post-I/R 3.7 ± 2.7%; = 0.9). Our data demonstrate that I/R injury similarly reduces endothelial function in women in the early follicular phase of the menstrual cycle and age-matched men with similar estradiol concentrations.
先前的数据表明，与卵泡早期相比，当雌二醇浓度最高时，卵泡晚期的女性可免受内皮细胞缺血再灌注（I/R）损伤。此外，在自然雌二醇浓度较低的男性中，内皮细胞 I/R 损伤也始终存在，这些男性的雌二醇浓度与卵泡早期的女性相似。因此，本研究的目的是确定在月经周期的卵泡早期的女性和年龄匹配的男性中，I/R 损伤的血管损伤作用是否存在差异。我们检验了如下假说，即具有相似循环雌二醇浓度的女性和年龄匹配的男性中，I/R 损伤对内皮依赖性血管舒张的影响程度相同。通过肱动脉血流介导的扩张（双功能超声）来评估内皮依赖性血管舒张，在 I/R 损伤之前（I/R 前）和之后（I/R 后）对年轻健康的男性（n=22）和女性（n=12）进行评估，I/R 损伤通过 20 分钟的手臂循环阻断然后再灌注 20 分钟来诱导。男女之间的雌二醇浓度没有差异（男性 115.0±33.9 pg·mL 与女性 90.5±40.8 pg·mL；=0.2）。I/R 损伤使内皮依赖性血管舒张减弱的程度在男性（I/R 前 5.4±2.4%与 I/R 后 3.0±2.7%；=0.9）和女性（I/R 前 6.1±2.8%与 I/R 后 3.7±2.7%；=0.9）之间没有差异。我们的数据表明，I/R 损伤以相似的方式降低月经周期卵泡早期的女性和具有相似雌二醇浓度的年龄匹配男性的内皮功能。
