Hubei Key Laboratory of Bioinorganic Chemistry & Materia Medica, School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan 430074, China.
Chem Soc Rev. 2021 Sep 7;50(17):9741-9765. doi: 10.1039/d1cs00317h. Epub 2021 Jul 14.
The ongoing coronavirus disease 2019 (COVID-19) pandemic has accelerated efforts to develop high-performance antiviral surface coatings while highlighting the need to build a strong mechanistic understanding of the chemical design principles that underpin antiviral surface coatings. Herein, we critically summarize the latest efforts to develop antiviral surface coatings that exhibit virus-inactivating functions through disrupting lipid envelopes or protein capsids. Particular attention is focused on how cutting-edge advances in material science are being applied to engineer antiviral surface coatings with tailored molecular-level properties to inhibit membrane-enveloped and non-enveloped viruses. Key topics covered include surfaces functionalized with organic and inorganic compounds and nanoparticles to inhibit viruses, and self-cleaning surfaces that incorporate photocatalysts and triplet photosensitizers. Application examples to stop COVID-19 are also introduced and demonstrate how the integration of chemical design principles and advanced material fabrication strategies are leading to next-generation surface coatings that can help thwart viral pandemics and other infectious disease threats.
正在持续的 2019 年冠状病毒病（COVID-19）大流行加速了开发高性能抗病毒表面涂层的努力，同时强调了需要建立对支持抗病毒表面涂层的化学设计原则的强大机械理解。在此，我们批判性地总结了最新的开发通过破坏脂质包膜或蛋白衣壳来表现出病毒失活功能的抗病毒表面涂层的努力。特别关注的是如何将材料科学的前沿进展应用于工程抗病毒表面涂层，以具有定制的分子级特性来抑制膜包膜和非包膜病毒。涵盖的关键主题包括用有机和无机化合物以及纳米粒子功能化表面以抑制病毒，以及包含光催化剂和三重态光敏剂的自清洁表面。还介绍了阻止 COVID-19 的应用示例，并展示了化学设计原则和先进材料制造策略的整合如何导致下一代表面涂层，可以帮助阻止病毒大流行和其他传染病威胁。
