近红外染料：广谱抗病毒药物的发展。

Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Miklukho-Maklaya 16/10, 117997 Moscow, Russia.

Department of Chemistry, Lomonosov Moscow State University, Leninskie Gory 1-3, 119991 Moscow, Russia.

Int J Mol Sci. 2022 Dec 22;24(1):188. doi: 10.3390/ijms24010188.

Broad antiviral activity in vitro is known for many organic photosensitizers generating reactive oxygen species under irradiation with visible light. Low tissue penetration of visible light prevents further development of antiviral therapeutics based on these compounds. One possible solution to this problem is the development of photosensitizers with near-infrared absorption (NIR dyes). These compounds found diverse applications in the photodynamic therapy of tumors and bacterial infections, but they are scarcely mentioned as antivirals. In this account, we aimed to evaluate the therapeutic prospects of various NIR-absorbing and singlet oxygen-generating chromophores for the development of broad-spectrum photosensitizing antivirals.

许多有机光增敏剂在可见光照射下会产生活性氧，具有广谱的体外抗病毒活性。可见光的组织穿透率低，限制了基于这些化合物的抗病毒疗法的进一步发展。解决这个问题的一个可能方法是开发具有近红外吸收（NIR 染料）的光增敏剂。这些化合物在肿瘤和细菌感染的光动力疗法中有多种应用，但作为抗病毒药物却很少被提及。在本报告中，我们旨在评估各种 NIR 吸收和单线态氧产生的生色团用于开发广谱光增敏抗病毒药物的治疗前景。