Marasini B, Biondi M L, Agostoni A
Clinica Medica V, Ospedale S. Paolo, University of Milan, Italy.
Angiology. 1987 Dec;38(12):878-82. doi: 10.1177/000331978703801202.
Plasma free and conjugated and intraplatelet free dopamine, norepinephrine, and epinephrine levels were determined by high-performance liquid chromatography coupled with electrochemical detection for 20 subjects with Raynaud's phenomenon of various etiologies. Circulating free dopamine and epinephrine were significantly lower in Raynaud's patients than in controls (dopamine 26.0 +/- 13.6 vs 56.3 +/- 39.6 pg/ml, p less than 0.005; epinephrine 25.8 +/- 16.9 vs 56.9 +/- 40.9 pg/ml, p less than 0.005), while the corresponding conjugated forms in plasma and the intraplatelet contents were within normal limits. There were no abnormalities in plasma free, conjugated, or intraplatelet free norepinephrine. All of the levels were independent of the etiology, the duration, and the severity of the disease. The reduced plasma levels of free dopamine and epinephrine might be due to impaired adrenal release in response to some kinds of sympathetic stimulation or to rapid tissue uptake and peripheral metabolism. A possible role for a postischemic dopaminergic vasodilating system is discussed.
采用高效液相色谱-电化学检测法，对20例不同病因的雷诺现象患者测定了血浆游离及结合型以及血小板内游离多巴胺、去甲肾上腺素和肾上腺素水平。雷诺病患者循环游离多巴胺和肾上腺素水平显著低于对照组（多巴胺26.0±13.6对56.3±39.6 pg/ml，p<0.005；肾上腺素25.8±16.9对56.9±40.9 pg/ml，p<0.005），而血浆中相应的结合型以及血小板内含量在正常范围内。血浆游离、结合型或血小板内游离去甲肾上腺素无异常。所有水平均与病因、病程及疾病严重程度无关。血浆游离多巴胺和肾上腺素水平降低可能是由于肾上腺对某些交感神经刺激的释放受损，或由于组织快速摄取和外周代谢所致。讨论了缺血后多巴胺能血管舒张系统的可能作用。
