雷诺现象患者的血浆游离和血小板内5-羟色胺

Plasma free and intraplatelet serotonin in patients with Raynaud's phenomenon.

作者信息

Biondi M L, Marasini B, Bianchi E, Agostoni A

机构信息

Clinica Medica V, University of Milan, Ospedale S. Paolo, Italy.

出版信息

Int J Cardiol. 1988 Jun;19(3):335-9. doi: 10.1016/0167-5273(88)90238-0.

DOI:10.1016/0167-5273(88)90238-0

PMID:3397197

Abstract

Plasma free and intraplatelet serotonin concentrations were measured by high-performance liquid chromatography coupled with electrochemical detection, in 30 patients with Raynaud's phenomenon of various etiologies. Serotonin was significantly higher in plasma (P less than 0.005) and in platelets (P less than 0.005) from Raynaud's patients than from normal controls. Moreover, plasma circulating serotonin could differentiate primary from secondary Raynaud's phenomenon, with significantly higher levels (P less than 0.05) for patients with an underlying connective tissue disease. Our data indicate a role for serotonin in Raynaud's phenomenon.

摘要

采用高效液相色谱法结合电化学检测法，对30例病因各异的雷诺现象患者测定了血浆游离血清素和血小板内血清素浓度。雷诺现象患者血浆（P<0.005）和血小板（P<0.005）中的血清素显著高于正常对照组。此外，血浆循环血清素可区分原发性和继发性雷诺现象，潜在结缔组织疾病患者的血清素水平显著更高（P<0.05）。我们的数据表明血清素在雷诺现象中起作用。