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在强迫症模拟样本中获得和维持厌恶反应:通过对抗条件作用程序进行消退策略的效率。

Acquisition and maintenance of disgust reactions in an OCD analogue sample: Efficiency of extinction strategies through a counter-conditioning procedure.

机构信息

Univ Paul Valéry Montpellier 3, Univ. Montpellier, EPSYLON EA 4556, Montpellier, France.

Groupe Ramsay Gds, Clinique RECH, Montpellier, France.

出版信息

PLoS One. 2021 Jul 14;16(7):e0254592. doi: 10.1371/journal.pone.0254592. eCollection 2021.

DOI:10.1371/journal.pone.0254592
PMID:34260646
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8279387/
Abstract

BACKGROUND

Obsessive-compulsive disorder (OCD) has long been considered as an anxiety disorder, disgust is the dominant emotion in contamination-based OCD. However, disgust seems resistant to exposure with response prevention partly due to the fact that disgust is acquired through evaluative conditioning.

AIMS

The present research investigates a counter-conditioning intervention in treating disgust-related emotional responses in two groups of individuals with high (High contamination concerns, HCC, n = 24) and low (Low contamination concerns LCC, n = 23) contamination concerns.

METHODS

The two groups completed a differential associative learning task in which neutral images were followed by disgusting images (conditioned stimulus; CS+), or not (CS-). Following this acquisition phase, there was a counter-conditioning procedure in which CS+ was followed by a very pleasant unconditional stimulus while CS- remained unreinforced.

RESULTS

Following counter-conditioning, both groups reported significant reduction in their expectancy of US occurrence and reported less disgust with CS+. For both expectancy and disgust, reduction was lower in the HCC group than in the LCC group. Disgust sensitivity was highly correlated with both acquisition and maintenance of the response acquired, while US expectation was predicted by anxiety.

CONCLUSION

Counter-conditioning procedure reduces both expectations and conditioned disgust.

摘要

背景

强迫症(OCD)长期以来一直被认为是一种焦虑症,在基于污染的 OCD 中,厌恶是主要情绪。然而,厌恶似乎对暴露和反应预防有抵抗力,部分原因是厌恶是通过评价性条件作用获得的。

目的

本研究在两组具有高(高污染担忧,HCC,n=24)和低(低污染担忧,LCC,n=23)污染担忧的个体中,调查了一种对抗条件作用的干预措施,以治疗与厌恶相关的情绪反应。

方法

两组参与者都完成了一个差异联想学习任务,其中中性图像后跟随令人厌恶的图像(条件刺激;CS+),或者不跟随(CS-)。在这个获得阶段之后,有一个对抗条件作用的程序,其中 CS+之后是一个非常愉快的无条件刺激,而 CS-则不受强化。

结果

对抗条件作用后,两组参与者都报告说 CS+的预期 US 发生的可能性和报告的厌恶程度都显著降低。对于期望和厌恶,HCC 组的降低幅度都低于 LCC 组。厌恶敏感性与反应获得和维持的相关性都很高,而 US 预期则由焦虑预测。

结论

对抗条件作用程序减少了预期和条件性厌恶。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1562/8279387/33618dbb8256/pone.0254592.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1562/8279387/33618dbb8256/pone.0254592.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1562/8279387/33618dbb8256/pone.0254592.g001.jpg

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