Bailenger J, Marcel P
U. E. R. Pharmacie, Bordeaux.
Ann Parasitol Hum Comp. 1987;62(5):426-33. doi: 10.1051/parasite/1987625426.
In order to establish the role played by prolactin in lactation during the evolution of Strongyloides ratti in the female rat, the authors tried to reproduce the effects of this physiological state by treatment with sulpiride (substituted benzamide), of which the prolactinogenic effect is intense in the female rat. Low doses partially reproduced the effects of lactation on parasitism by diminishing its intensity and delaying the onset of rejection, although without preventing it. The pharmacological action of sulpiride, which acts by blocking the dopamine receptors, explains why only low doses are active and why their action is limited to the onset of parasitism. This experiment lends weight to the hypothesis that prolactin plays a fundamental role in modifications of the evolution of Strongyloides ratti during lactation.
为了确定催乳素在雌性大鼠体内感染鼠类圆线虫过程中的泌乳作用，作者试图通过使用舒必利（取代苯甲酰胺）进行治疗来重现这种生理状态的影响，舒必利对雌性大鼠具有强烈的催乳素生成作用。低剂量药物通过降低寄生虫感染强度和延迟排斥反应的发生，部分重现了泌乳对寄生虫感染的影响，尽管未能阻止排斥反应。舒必利通过阻断多巴胺受体发挥药理作用，这解释了为何只有低剂量药物具有活性，以及其作用为何仅限于寄生虫感染初期。该实验支持了催乳素在泌乳期间鼠类圆线虫感染演变的改变中起重要作用这一假说。
