2型糖尿病患者中腺苷脱氨酶与心率校正QT间期的关系。
The relationship between adenosine deaminase and heart rate-corrected QT interval in type 2 diabetic patients.
作者信息
Lu Chun-Feng, Ge Xiao-Qin, Wang Yan, Su Jian-Bin, Wang Xue-Qin, Zhang Dong-Mei, Xu Feng, Liu Wang-Shu, Su Min
机构信息
Department of Endocrinology, Affiliated Hospital 2 of Nantong University and First People's Hospital of Nantong City, Nantong, China.
Department of Geriatrics, Affiliated Hospital 2 of Nantong University and First People's Hospital of Nantong City, Nantong, China.
出版信息
Endocr Connect. 2021 Aug 3;10(8):894-901. doi: 10.1530/EC-21-0199.
BACKGROUND
Prolonged heart rate-corrected QT (QTc) interval may reflect poor prognosis of patients with type 2 diabetes (T2D). Serum adenosine deaminase (ADA) levels are related to hyperglycemia, insulin resistance (IR) and inflammation, which may participate in diabetic complications. We investigated the association of serum ADA levels with prolonged QTc interval in a large-scale sample of patients with T2D.
METHODS
In this cross-sectional study, a total of 492 patients with T2D were recruited. Serum ADA levels were determined by venous blood during fasting. QTc interval was estimated from resting 12-lead ECGs, and prolonged QTc interval was defined as QTc > 440 ms.
RESULTS
In this study, the prevalence of prolonged QTc interval was 22.8%. Serum ADA levels were positively associated with QTc interval (r = 0.324, P < 0.0001). The proportion of participants with prolonged QTc interval increased significantly from 9.2% in the first tertile (T1) to 24.7% in the second tertile (T2) and 39.0% in the third tertile (T3) of ADA (P for trend < 0.001). After adjusting for other possible risk factors by multiple linear regression analysis, serum ADA level was still significantly associated with QTc interval (β = 0.217, t = 3.400, P < 0.01). Multivariate logistic regression analysis showed that female (OR 5.084, CI 2.379-10.864, P < 0.001), insulin-sensitizers treatment (OR 4.229, CI 1.290-13.860, P = 0.017) and ADA (OR 1.212, CI 1.094-1.343, P < 0.001) were independent contributors to prolonged QTc interval.
CONCLUSIONS
Serum ADA levels were independently associated with prolonged QTc interval in patients with T2D.
背景
心率校正的QT（QTc）间期延长可能反映2型糖尿病（T2D）患者的预后不良。血清腺苷脱氨酶（ADA）水平与高血糖、胰岛素抵抗（IR）及炎症相关，这些因素可能参与糖尿病并发症的发生。我们在一个大规模的T2D患者样本中研究了血清ADA水平与QTc间期延长之间的关联。
方法
在这项横断面研究中，共纳入492例T2D患者。空腹时通过静脉血测定血清ADA水平。从静息12导联心电图估算QTc间期，QTc间期延长定义为QTc>440毫秒。
结果
在本研究中，QTc间期延长的患病率为22.8%。血清ADA水平与QTc间期呈正相关（r = 0.324，P < 0.0001）。ADA处于第一个三分位数（T1）的参与者中QTc间期延长的比例为9.2%，在第二个三分位数（T2）中显著增加至24.7%，在第三个三分位数（T3）中为39.0%（趋势P < 0.001）。通过多元线性回归分析校正其他可能的危险因素后，血清ADA水平仍与QTc间期显著相关（β = 0.217，t = 3.400，P < 0.01）。多因素逻辑回归分析显示，女性（OR 5.084，CI 2.379 - 10.864，P < 0.001）、胰岛素增敏剂治疗（OR 4.229，CI 1.290 - 13.860，P = 0.017）和ADA（OR 1.212，CI 1.094 - 1.
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