肾脏中研究较少的 G 蛋白偶联受体。
Understudied G Protein-Coupled Receptors in the Kidney.
机构信息
Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
出版信息
Nephron. 2022;146(3):278-281. doi: 10.1159/000517355. Epub 2021 Jul 14.
Abstract
G protein-coupled receptors (GPCRs) are cell surface proteins which play a key role in allowing cells, tissues, and organs to respond to changes in the external environment in order to maintain homeostasis. Despite the fact that GPCRs are known to play key roles in a variety of tissues, there are a large subset of GPCRs that remain poorly studied. In this minireview, we will summarize what is known regarding the "understudied" GPCRs with respect to renal function, and in so doing will highlight the promise represented by studying this gene family.
摘要
G 蛋白偶联受体（GPCRs）是细胞表面蛋白，在使细胞、组织和器官对外部环境变化做出响应以维持内环境稳定方面发挥着关键作用。尽管已知 GPCRs 在多种组织中发挥着关键作用，但仍有很大一部分 GPCRs 研究不足。在这篇迷你综述中，我们将总结关于“研究不足”的 GPCRs 与肾功能的已知内容，并借此强调研究这个基因家族所代表的前景。
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