Rajkumar P, Pluznick J L
Department of Physiology, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Acta Physiol (Oxf). 2017 Jun;220(2):189-200. doi: 10.1111/apha.12813. Epub 2016 Oct 23.
Recent studies have shown that orphan GPCRs of the GPR family are utilized as specialized chemosensors in various tissues to detect metabolites, and in turn to activate downstream pathways which regulate systemic homeostasis. These studies often find that such metabolites are generated by well-known metabolic pathways, implying that known metabolites and chemicals may perform novel functions. In this review, we summarize recent findings highlighting the role of deorphanized GPRs in renal development and function. Understanding the role of these receptors is critical in gaining insights into mechanisms that regulate renal function both in health and in disease.
最近的研究表明，GPR家族的孤儿GPCRs在各种组织中被用作特殊的化学传感器来检测代谢物，进而激活调节全身稳态的下游通路。这些研究经常发现，此类代谢物是由众所周知的代谢途径产生的，这意味着已知的代谢物和化学物质可能具有新的功能。在这篇综述中，我们总结了最近的研究发现，突出了已明确功能的GPRs在肾脏发育和功能中的作用。了解这些受体的作用对于深入了解健康和疾病状态下调节肾功能的机制至关重要。
