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迟发性骨结核:一例报告

Late Discovering Spina Ventosa: A Case Report.

作者信息

Nguyen Ngoc Sang, Nguyen Thai Ha, Vu Van Quang, Vu Tung Lam, Nguyen Ngoc Rang, Nguyen Van Hung

机构信息

Haiphong University of Medicine and Pharmacy, Hai Phong, Vietnam.

An Giang Central General Hospital, An Giang, Vietnam.

出版信息

Int Med Case Rep J. 2021 Jul 5;14:449-453. doi: 10.2147/IMCRJ.S318003. eCollection 2021.

Abstract

INTRODUCTION

Spina Ventosa is a rare condition that is easy to misdiagnose as other diseases. We present a case of late-diagnosed Spina Ventosa, which had not only the osteoarticular tuberculosis symptoms but also some severe symptoms, including pleural effusion, ascites, and anemia. By intensive treatment, our patient recovered completely.

CASE REPORT

A 7-year-old boy was admitted with complaints of painless swelling of metacarpals, metatarsals, and phalanges of his hands and feet and a discharging sinus of the left toe. There was no family or past history of tuberculosis. His immunizations were up to date. General examination revealed that the child had pallor and was emaciated. No lymphadenopathy was detected. Investigations revealed hemoglobin: 74 g/l, and erythrocyte sedimentation rate (ESR) was 42 mm/hour. QuantiFERON-TB test was positive. The radiograph showed irregular swelling with sclerosis of the underlying bones. The right-hand x-ray showed cortical destruction, sclerosis, and cystic expansion or right second metacarpal. Chest x-ray indicated pleural effusion. Histopathological examination of specimen from the foot and lung and abdomen fluid confirmed tuberculosis. The child was treated with the first-line tuberculosis treatment regimen (Isoniazid, Rifampicin, Ethambutol, and Pyrazinamide) for two months, followed by Isoniazid, Rifampicin, and Pyrazinamide for a further four months. His lesions disappeared after six weeks of intensive treatment.

CONCLUSION

A delay in diagnosis and treatment of tuberculosis can lead to systemic manifestations in multiple organs. Despite the delay in diagnosis, this child had a good outcome due to being treated promptly and adequately after the presentation.

摘要

引言

骨结核是一种罕见疾病,容易被误诊为其他疾病。我们报告一例晚期诊断的骨结核病例,该病例不仅有骨关节结核症状,还伴有一些严重症状,包括胸腔积液、腹水和贫血。经过强化治疗,我们的患者完全康复。

病例报告

一名7岁男孩因手足掌骨、跖骨和指骨无痛性肿胀以及左脚趾有排脓窦道入院。其家族史和既往史均无结核病。他的免疫接种均在有效期内。全身检查发现该患儿面色苍白且消瘦。未检测到淋巴结肿大。检查结果显示血红蛋白为74g/L,红细胞沉降率(ESR)为42mm/小时。结核菌素试验呈阳性。X线片显示下方骨骼有不规则肿胀并伴有硬化。右手X线显示皮质破坏、硬化以及右第二掌骨囊性扩张。胸部X线提示胸腔积液。足部、肺部和腹腔积液标本的组织病理学检查确诊为结核病。该患儿先用一线抗结核治疗方案(异烟肼、利福平、乙胺丁醇和吡嗪酰胺)治疗两个月,随后继续使用异烟肼、利福平和吡嗪酰胺治疗四个月。经过六周的强化治疗,他的病灶消失。

结论

结核病诊断和治疗的延迟可导致多器官的全身表现。尽管诊断延迟,但该患儿在出现症状后因得到及时、充分的治疗而预后良好。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/69a0/8273899/c73851b55663/IMCRJ-14-449-g0001.jpg

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