Rozen Genia, Sii Stephanie, Agresta Franca, Gook Debra, Polyakov Alex, Stern Catharyn
Reproductive Services Unit Royal Women's Hospital Parkville, Melbourne Vic. Australia.
Reprod Med Biol. 2021 May 12;20(3):277-288. doi: 10.1002/rmb2.12380. eCollection 2021 Jul.
Uncertainties remain regarding the clinical efficacy of ovarian tissue cryopreservation and grafting. We report a retrospective analysis of reproductive outcomes and lessons learnt following 55 ovarian tissue transplant procedures at our center from 2006 to 2019.
We analyzed variables related to graft success such as tissue volume, follicular density, total follicular volume, and age on the duration of graft function.
Follicular density and total follicular volume correlate positively with duration of graft function. All clinical pregnancies in our cohort occurred in women who were aged 35 or less at the time of ovarian tissue cryopreservation.
Graft success, as determined by eventual pregnancy and the longevity of graft function, may be impacted by factors including age at cryopreservation, follicular density, and total follicular volume.
卵巢组织冷冻保存及移植的临床疗效仍存在不确定性。我们报告了对2006年至2019年在本中心进行的55例卵巢组织移植手术的生殖结局及经验教训的回顾性分析。
我们分析了与移植成功相关的变量，如组织体积、卵泡密度、卵泡总体积以及年龄对移植功能持续时间的影响。
卵泡密度和卵泡总体积与移植功能持续时间呈正相关。我们队列中的所有临床妊娠均发生在卵巢组织冷冻保存时年龄在35岁及以下的女性中。
由最终妊娠及移植功能持续时间所确定的移植成功，可能受到包括冷冻保存时的年龄、卵泡密度和卵泡总体积等因素的影响。
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