Donfack N J, Alves K A, Araújo V R, Cordova A, Figueiredo J R, Smitz J, Rodrigues A P R
Faculty of Veterinary Medicine,Laboratory of Manipulation of Oocytes and Preantral Follicles (LAMOFOPA),State University of Ceará,Fortaleza,CE,Brazil.
Department of Biomedical Sciences,Ontario Veterinary College,University of Guelph,50 Stone Road,Guelph,ON N1G 2W1,Canada.
Zygote. 2017 Aug;25(4):391-403. doi: 10.1017/S0967199417000338. Epub 2017 Aug 2.
Constant progress in the diagnosis and treatment of cancer disease has increased the number and prognosis of cancer survivors. However, the toxic effects of chemotherapy and radiotherapy on ovarian function have resulted in premature ovarian failure. Patients are, therefore, still expecting methods to be developed to preserve their fertility successfully. Several potential options are available to preserve fertility in patients who face premature ovarian failure, including immature or mature oocyte and embryo cryopreservation. However, for children or prepubertal women needing immediate chemotherapy, cryopreservation of ovarian tissue is the only alternative. The ultimate aim of this strategy is to implant ovarian tissue into the pelvic cavity (orthotopic site) or in a heterotopic site once oncological treatment is completed and the patient is disease free. Transplantation of ovarian tissue with sufficiently large numbers of follicles could potentially restore endocrine function and allow multiple cycles for conception. However, the success of ovarian tissue transplantation still has multiple challenges, such as the low number of follicles in the graft that may affect their longevity as well as the survival of the tissue during ex vivo processing and subsequent transplantation. Therefore, this review aims to summarize the achievements of ovary grafting and the potential techniques that have been developed to improve ovarian graft survival.
癌症疾病诊断和治疗方面的不断进步增加了癌症幸存者的数量并改善了其预后。然而，化疗和放疗对卵巢功能的毒性作用导致了卵巢早衰。因此，患者仍期待能成功开发出保留生育能力的方法。对于面临卵巢早衰的患者，有几种保留生育能力的潜在选择，包括未成熟或成熟卵母细胞及胚胎冷冻保存。然而，对于需要立即进行化疗的儿童或青春期前女性，卵巢组织冷冻保存是唯一的选择。该策略的最终目标是在肿瘤治疗完成且患者无疾病后，将卵巢组织植入盆腔（原位）或异位部位。移植含有足够数量卵泡的卵巢组织可能会恢复内分泌功能并实现多次受孕周期。然而，卵巢组织移植的成功仍面临多重挑战，例如移植物中卵泡数量少可能会影响其寿命，以及离体处理和后续移植过程中组织的存活。因此，本综述旨在总结卵巢移植的成果以及为提高卵巢移植物存活率而开发出的潜在技术。
