黄嘌呤氧化还原酶存在于人体滑膜中。
Xanthine oxidoreductase is present in human synovium.
作者信息
Allen R E, Outhwaite J M, Morris C J, Blake D R
机构信息
Rheumatism Research Wing, Medical School, Birmingham.
出版信息
Ann Rheum Dis. 1987 Nov;46(11):843-5. doi: 10.1136/ard.46.11.843.
Abstract
It is postulated that the mobile inflamed joint may be subject to cyclical ischaemic reperfusion injury. Xanthine oxidoreductase is an enzyme thought to contribute to oxidative reperfusion injury, and the detection of this activity in human synovium is described. Three normal and five rheumatoid tissues were assayed with a carbon-14 radioassay detecting the conversion of [14C]xanthine to [14C]uric acid. Rheumatoid synovia contained 0.67-305 microU/g tissue (n = 5), while normal synovia contained 1.2-5.0 microU/g tissue (n = 3).
摘要
据推测，活动的炎症关节可能会遭受周期性缺血再灌注损伤。黄嘌呤氧化还原酶是一种被认为会导致氧化再灌注损伤的酶，本文描述了在人体滑膜中对该酶活性的检测。采用碳 - 14放射性测定法检测[14C]黄嘌呤向[14C]尿酸的转化，对三个正常组织和五个类风湿组织进行了检测。类风湿滑膜组织中该酶的含量为0.67 - 305微单位/克组织（n = 5），而正常滑膜组织中该酶的含量为1.2 - 5.0微单位/克组织（n = 3）。
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