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黄嘌呤氧化酶在滑膜内皮细胞中的定位。

Localisation of xanthine oxidase to synovial endothelium.

作者信息

Stevens C R, Benboubetra M, Harrison R, Sahinoglu T, Smith E C, Blake D R

机构信息

ARC Bone and Joint Research Unit, London Hospital Medical College, UK.

出版信息

Ann Rheum Dis. 1991 Nov;50(11):760-2. doi: 10.1136/ard.50.11.760.

DOI:10.1136/ard.50.11.760
PMID:1772289
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1004552/
Abstract

The presence of the xanthine oxidase enzyme system has been demonstrated in the rheumatoid synovium. This supplies a reactive oxygen species generating system to synovium that is subjected to hypoxic-reperfusion cycles (cf inflamed rheumatoid synovium). An antibody to bovine milk xanthine oxidase has been used to localise the enzyme by immunohistochemistry to synovial endothelium. This implicates the endothelial cell as playing a major part in exacerbations of synovitis, induced by radicals.

摘要

在类风湿性滑膜炎中已证实存在黄嘌呤氧化酶系统。这为经历缺氧-再灌注循环的滑膜提供了一个活性氧生成系统（如发炎的类风湿性滑膜）。一种针对牛乳黄嘌呤氧化酶的抗体已被用于通过免疫组织化学将该酶定位到滑膜内皮细胞。这表明内皮细胞在自由基诱导的滑膜炎加重中起主要作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf45/1004552/8f3c7d73cb78/annrheumd00460-0021-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf45/1004552/91de93de1812/annrheumd00460-0021-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf45/1004552/8f3c7d73cb78/annrheumd00460-0021-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf45/1004552/91de93de1812/annrheumd00460-0021-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf45/1004552/8f3c7d73cb78/annrheumd00460-0021-b.jpg

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本文引用的文献

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Preparation of bovine milk xanthine oxidase as a dehydrogenase form.将牛乳黄嘌呤氧化酶制备成脱氢酶形式。
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Is chronic synovitis an example of reperfusion injury?
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不同风湿性疾病中F(2)-异前列腺素和前列腺素F(2α)水平升高。
Ann Rheum Dis. 2001 Jun;60(6):627-31. doi: 10.1136/ard.60.6.627.
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Induction and activation of procollagenase in rabbit synovial fibroblasts after treatment with active oxygen released by xanthine/xanthine oxidase.用黄嘌呤/黄嘌呤氧化酶释放的活性氧处理后兔滑膜成纤维细胞中前胶原酶的诱导与激活
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Inhibition of poly(ADP-ribose) formation by 4-hydroxynonenal in primary cultures of rabbit synovial fibroblasts.4-羟基壬烯醛对兔滑膜成纤维细胞原代培养物中聚（ADP-核糖）形成的抑制作用。
Biochem J. 1996 May 1;315 ( Pt 3)(Pt 3):705-8. doi: 10.1042/bj3150705.
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Electron spin resonance spectroscopic demonstration of the generation of reactive oxygen species by diseased human synovial tissue following ex vivo hypoxia-reoxygenation.电子自旋共振光谱法证实离体缺氧-复氧后病变人类滑膜组织产生活性氧。
Ann Rheum Dis. 1995 Feb;54(2):94-9. doi: 10.1136/ard.54.2.94.
8
Oxygen radicals, nitric oxide and human inflammatory joint disease.氧自由基、一氧化氮与人类炎性关节疾病
Ann Rheum Dis. 1995 Jun;54(6):505-10. doi: 10.1136/ard.54.6.505.
9
2nd International meeting on synovium cell biology, physiology and pathology. Canterbury, United Kingdom, 21-23 September 1994. Proceedings and abstracts.第二届滑膜细胞生物学、生理学及病理学国际会议。英国坎特伯雷，1994年9月21日至23日。会议论文集及摘要
Ann Rheum Dis. 1995 Jun;54(6):501-28. doi: 10.1136/ard.54.6.501-a.
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Ann Rheum Dis. 1986 Jul;45(7):608-11. doi: 10.1136/ard.45.7.608.
4
Significance of xanthine oxidase in capillary endothelial cells.黄嘌呤氧化酶在毛细血管内皮细胞中的意义。
Acta Physiol Scand Suppl. 1986;548:39-46.
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Xanthine oxidoreductase is present in human synovium.黄嘌呤氧化还原酶存在于人体滑膜中。
Ann Rheum Dis. 1987 Nov;46(11):843-5. doi: 10.1136/ard.46.11.843.
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Inhibition of human endothelial cell proliferation by gold compounds.金化合物对人内皮细胞增殖的抑制作用。
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Superoxide radical generation by inflamed human synovium after hypoxia.缺氧后炎症状态下的人体滑膜产生超氧阴离子自由基。
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Hypoxic-reperfusion injury in the inflamed human joint.炎症状态下人体关节的缺氧再灌注损伤
Lancet. 1989 Feb 11;1(8633):289-93. doi: 10.1016/s0140-6736(89)91305-6.
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Influence of disodium aurothiomalate on the activities of xanthine dehydrogenase and xanthine oxidase in endothelial cells.金硫葡糖钠对内皮细胞中黄嘌呤脱氢酶和黄嘌呤氧化酶活性的影响。
Agents Actions Suppl. 1991;32:71-5. doi: 10.1007/978-3-0348-7405-2_9.