Nutrition and Diet Policlinic, Akyurt Devlet Hastanesi, Akyurt, Ankara, Turkey.
Faculty of Health Science, Department of Nutrition and Dietetic, Gazi University, Emek, Ankara, Turkey.
J Am Nutr Assoc. 2022 Jan;41(1):50-56. doi: 10.1080/07315724.2020.1846635. Epub 2021 Jul 15.
Obesity has been increasingly recognized in pediatric acute lymphoblastic leukemia (ALL) survivors. The aim of the current study was to determine the prevelance and related factors of obesity/abdominal obesity and evaluate the association between nutrition and overweight/obesity after cancer treatment in pediatric ALL survivors.
An observational retrospective cohort study was performed among 67 volunteers (aged 5-15). Participants completed 3 consecutive days (2 weekdays and 1 weekend day) recording food consumption and physical activity simultaneously. Weight, height, and waist circumference measurements were performed in remission period, and retrospective data were obtained from patient records. We examined data at three periods: diagnosis, end of treatment, and remission. Subjects were classified into four groups according to body mass index for age score (BAZ): underweight, normal weight, overweight, and obese. Abdominal obesity was defined waist-to-height ratio ≥ 0.5.
Prevalence of overweight, obesity, and abdominal obesity were 25.3%, 23.9%, 38.8%, respectively in remission. BAZ at diagnosis and at treatment completion, dietary energy intake, and physical activity were associated with an increased risk of being overweight/obese in remission ( < .05). Gender, age at diagnosis, cranial radiotherapy, and treatment risk category were not significant ( > .05).
As in obesity, abdominal obesity was found an important problem in pediatric ALL survivors. Therefore, nutritional targets are needed to prevent obesity. Survivors should be closely monitored in terms of nutritional status during and after treatment and informed about and supported for healthy lifestyle (balanced and adequate nutrition, increase in physical activity).
肥胖在儿科急性淋巴细胞白血病（ALL）幸存者中越来越受到关注。本研究旨在确定肥胖/腹型肥胖的患病率及相关因素，并评估癌症治疗后儿科 ALL 幸存者营养与超重/肥胖的关系。
对 67 名志愿者（年龄 5-15 岁）进行了一项观察性回顾性队列研究。参与者连续 3 天（2 个工作日和 1 个周末）同时记录食物摄入量和身体活动。在缓解期进行体重、身高和腰围测量，并从患者记录中获取回顾性数据。我们检查了诊断、治疗结束和缓解三个时期的数据。根据体重指数年龄得分（BAZ）将受试者分为 4 组：体重不足、正常体重、超重和肥胖。腹型肥胖定义为腰高比≥0.5。
缓解期超重、肥胖和腹型肥胖的患病率分别为 25.3%、23.9%和 38.8%。诊断时和治疗结束时的 BAZ、膳食能量摄入和体力活动与缓解期超重/肥胖的风险增加相关（ < .05）。性别、诊断时年龄、颅放疗和治疗风险类别无显著差异（ > .05）。
与肥胖一样，腹型肥胖也是儿科 ALL 幸存者的一个重要问题。因此，需要针对营养目标来预防肥胖。在治疗期间和治疗后，应密切监测幸存者的营养状况，并告知和支持他们采取健康的生活方式（均衡充足的营养、增加体力活动）。
