抗 GM-CSF 自身抗体在感染新型隐球菌和格特隐球菌的 HIV 阴性哥伦比亚患者中的作用。
Autoantibodies Neutralizing GM-CSF in HIV-Negative Colombian Patients Infected with Cryptococcus gattii and C. neoformans.
机构信息
Group of Inborn Errors of Immunity (Primary Immunodeficiencies), Department of Microbiology and Parasitology, School of Medicine, University of Antioquia (UdeA), Medellín, Colombia.
Laboratory of Human Genetics of Infectious Diseases. Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France.
出版信息
J Clin Immunol. 2024 Jul 15;44(7):163. doi: 10.1007/s10875-024-01757-y.
BACKGROUND
Cryptococcosis is a life-threatening disease caused by Cryptococcus neoformans or C. gattii. Neutralizing autoantibodies (auto-Abs) against granulocyte-macrophage colony-stimulating factor (GM-CSF) in otherwise healthy adults with cryptococcal meningitis have been described since 2013. We searched for neutralizing auto-Abs in sera collected from Colombian patients with non-HIV-associated cryptococcosis in a retrospective national cohort from 1997 to 2016.
METHODS
We reviewed clinical and laboratory records and assessed the presence of neutralizing auto-Abs against GM-CSF in 30 HIV negative adults with cryptococcosis (13 caused by C. gattii and 17 caused by C. neoformans).
RESULTS
We detected neutralizing auto-Abs against GM-CSF in the sera of 10 out of 13 (77%) patients infected with C. gattii and one out of 17 (6%) patients infected with C. neoformans.
CONCLUSIONS
We report eleven Colombian patients diagnosed with cryptococcosis who had auto-Abs that neutralize GM-CSF. Among these patients, ten were infected with C. gattii and only one with C. neoformans.
背景
隐球菌病是由新型隐球菌或格特隐球菌引起的危及生命的疾病。自 2013 年以来，在患有隐球菌性脑膜炎的其他健康成年人中，已经描述了针对粒细胞-巨噬细胞集落刺激因子（GM-CSF）的中和自身抗体（auto-Abs）。我们在 1997 年至 2016 年期间的回顾性全国队列中，从哥伦比亚非 HIV 相关隐球菌病患者的血清中搜索了中和自身抗体。
方法
我们回顾了临床和实验室记录，并评估了 30 名 HIV 阴性隐球菌病（13 名由 C. gattii 引起，17 名由 C. neoformans 引起）成年人中针对 GM-CSF 的中和自身抗体的存在情况。
结果
我们在 13 名（77%）感染 C. gattii 的患者和 17 名（6%）感染 C. neoformans 的患者的血清中检测到针对 GM-CSF 的中和自身抗体。
结论
我们报告了 11 名被诊断患有隐球菌病的哥伦比亚患者，他们的自身抗体可以中和 GM-CSF。在这些患者中，有 10 人感染了 C. gattii，只有 1 人感染了 C. neoformans。
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