Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, 161 Cathedral Street, G4 0RE Glasgow, U.K.
GSK, Via Fiorentina 1, 53100 Siena, Italy.
Mol Pharm. 2021 Aug 2;18(8):2867-2888. doi: 10.1021/acs.molpharmaceut.1c00447. Epub 2021 Jul 15.
Despite the many advances that have occurred in the field of vaccine adjuvants, there are still unmet needs that may enable the development of vaccines suitable for more challenging pathogens (e.g., HIV and tuberculosis) and for cancer vaccines. Liposomes have already been shown to be highly effective as adjuvant/delivery systems due to their versatility and likely will find further uses in this space. The broad potential of lipid-based delivery systems is highlighted by the recent approval of COVID-19 vaccines comprising lipid nanoparticles with encapsulated mRNA. This review provides an overview of the different approaches that can be evaluated for the design of lipid-based vaccine adjuvant/delivery systems for protein, carbohydrate, and nucleic acid-based antigens and how these strategies might be combined to develop multicomponent vaccines.
尽管疫苗佐剂领域已经取得了许多进展，但仍存在未满足的需求，这可能使我们能够开发出适用于更具挑战性的病原体（例如 HIV 和结核病）和癌症疫苗的疫苗。由于脂质体的多功能性，它们已经被证明是非常有效的佐剂/递送系统，并且可能会在这一领域有更多的应用。最近，包含封装 mRNA 的脂质纳米颗粒的 COVID-19 疫苗获得批准，这凸显了基于脂质的递药系统的广泛潜力。这篇综述概述了可用于设计基于脂质的疫苗佐剂/递送系统的不同方法，这些系统可用于蛋白质、碳水化合物和核酸抗原，以及如何结合这些策略来开发多组分疫苗。
